ZM306416 | B2915

ZM 306416 is an inhibitor of vascular endothelial growth factor (VEGF) receptor tyrosine kinase. It inhibits the activity of KDR and Flt VEGF receptors with IC₅₀ values of 100 nM and 2 μM, respectively. It is also a potent inhibitor of EGFR with an IC₅₀ value below 10 nM in a luminescence ADP production kinase assay.

ZM 306416 is an inhibitor of vascular endothelial growth factor (VEGF) receptor tyrosine kinase. It inhibits the activity of KDR and Flt VEGF receptors with IC₅₀ values of 100 nM and 2 μM, respectively. It is also a potent inhibitor of EGFR with an IC₅₀ value below 10 nM in a luminescence ADP production kinase assay.

B2915 | ZM306416 DataSheet

Alternate Name/Synonyms: N-(4-chloro-2-fluorophenyl)-6,7-dimethoxyquinazolin-4-amine; 4-[(4'-Chloro-2'-fluoro)phenylamino]-6,7-dimethoxyquinazoline; CB-676475

Appearance: A crystalline solid

Formulation:

CAS Number: 690206-97-4

Structure Available?: True

Peptide sequence:

Salt Form: false

Molecular Formula: C₁₆H₁₃ClFN₃O₂

Molecular Weight: 333.74

Cell-Permeable?: True

Purity: ≥98%

Solubilities: ~20 mg/ml in in Ethanol, ~50 mg/ml in DMSO and DMF in 0

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: An inhibitor of VEGF(KDR and Flt) receptor tyrosine kinase

MDL Number: MFCD02683969

PubChem CID: 5329006

SMILES: COC1=C(C=C2C(=C1)C(=NC=N2)NC3=C(C=C(C=C3)Cl)F)OC

InChi: InChI=1S/C16H13ClFN3O2/c1-22-14-6-10-13(7-15(14)23-2)19-8-20-16(10)21-12-4-3-9(17)5-11(12)18/h3-8H,1-2H3,(H,19,20,21)

InChi Key: