Description
ZM 306416 is an inhibitor of vascular endothelial growth factor (VEGF) receptor tyrosine kinase. It inhibits the activity of KDR and Flt VEGF receptors with IC₅₀ values of 100 nM and 2 μM, respectively. It is also a potent inhibitor of EGFR with an IC₅₀ value below 10 nM in a luminescence ADP production kinase assay.
ZM 306416 is an inhibitor of vascular endothelial growth factor (VEGF) receptor tyrosine kinase. It inhibits the activity of KDR and Flt VEGF receptors with IC₅₀ values of 100 nM and 2 μM, respectively. It is also a potent inhibitor of EGFR with an IC₅₀ value below 10 nM in a luminescence ADP production kinase assay.
Alternate Name/Synonyms: N-(4-chloro-2-fluorophenyl)-6,7-dimethoxyquinazolin-4-amine; 4-[(4'-Chloro-2'-fluoro)phenylamino]-6,7-dimethoxyquinazoline; CB-676475
Appearance: A crystalline solid
Formulation:
CAS Number: 690206-97-4
Structure Available?: True
Peptide sequence:
Salt Form: false
Molecular Formula: C₁₆H₁₃ClFN₃O₂
Molecular Weight: 333.74
Cell-Permeable?: True
Purity: ≥98%
Solubilities: ~20 mg/ml in in Ethanol, ~50 mg/ml in DMSO and DMF in 0
Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Country of Origin: USA
Tag Line: An inhibitor of VEGF(KDR and Flt) receptor tyrosine kinase
MDL Number: MFCD02683969
PubChem CID: 5329006
SMILES: COC1=C(C=C2C(=C1)C(=NC=N2)NC3=C(C=C(C=C3)Cl)F)OC
InChi: InChI=1S/C16H13ClFN3O2/c1-22-14-6-10-13(7-15(14)23-2)19-8-20-16(10)21-12-4-3-9(17)5-11(12)18/h3-8H,1-2H3,(H,19,20,21)
InChi Key:
Additional Information
Storage Condition: |
-20ºC |
Shipping Condition: |
RT |
Shelf Life: |
36 months |