ZMYM2 Antibody | 6135

ZMYM2 Antibody | 6135 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, Mouse, Rat

Homology: N/A

Immunogen: ZMYM2 antibody was raised against a 17 amino acid peptide near the amino terminus of human ZMYM2.
The immunogen is located within amino acids 120 - 170 of ZMYM2.

Research Area: Homeostasis

Tested Application: E, WB, ICC, IF

Application: ZMYM2 antibody can be used for detection of ZMYM2 by Western blot at 0. 125 - 0.25 μg/mL. Antibody can also be used for immunocytochemistry starting at 10 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in mouse samples; Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Specificiy: At least two isoforms of ZMYM2 are known to exist; this antibody will detect only the longest isoform. ZMYM2 antibody is predicted to not cross-react with other ZMYM protein family members.

Positive Control 1: Cat. No. 1462 - Rat Lung Tissue Lysate

Positive Control 2: Cat. No. 17-001 - HeLa Cell Slide

Positive Control 3: N/A

Positive Control 4: N/A

Positive Control 5: N/A

Positive Control 6: N/A

Molecular Weight: N/A

Validation: N/A

Isoform: N/A

Purification: ZMYM2 Antibody is affinity chromatography purified via peptide column.

Clonality: Polyclonal

Clone: N/A

Isotype: IgG

Conjugate: Unconjugated

Physical State: Liquid

Buffer: ZMYM2 Antibody is supplied in PBS containing 0.02% sodium azide.

Concentration: 1 mg/mL

Storage Condition: ZMYM2 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Alternate Name: ZMYM2 Antibody: FIM, MYM, RAMP, SCLL, ZNF198, FIM, Zinc finger MYM-type protein 2, Fused in myeloproliferative disorders protein

User Note: Optimal dilutions for each application to be determined by the researcher.

BACKGROUND: Zinc-finger proteins contain DNA-binding domains characterized by the unique role of zinc and have a wide variety of functions such as transcriptional activation or repression (1) . The protein folding and the DNA binding ability are governed by the coordination of a zinc ion (1-3) . As a member of the MYM (myeloproliferative and mental retardation) gene family, ZMYM2 has been shown to associate with and stabilize the LSD1-CoREST-HDAC1 (LCH) complex of chromatin through its MYM-type zinc fingers, thereby enhancing the transcriptional repression of several genes (4) . Translocation of this gene with the fibroblast growth factor receptor-1 gene (FGFR1) results in a fusion gene, which may be a cause of stem cell leukemia lymphoma syndrome (SCLL) (5) .