ZNF451 polyclonal Antibody | BS72710

ZNF451 polyclonal Antibody | BS72710 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat

Application: WB,IHC

Application Range: WB 1:2000 - 1:5000 IHC 1:50 - 1:200

Background: E3 SUMO-protein ligase; has a preference for SUMO2 and SUMO3 and facilitates UBE2I/UBC9-mediated sumoylation of target proteins. Plays a role in protein SUMO2 modification in response to stress caused by DNA damage and by proteasome inhibitors (in vitro) . Required for MCM4 sumoylation. Has no activity with SUMO1. Preferentially transfers an additional SUMO2 chain onto the SUMO2 consensus site 'Lys-11' . Negatively regulates transcriptional activation mediated by the SMAD4 complex in response to TGF-beta signaling. Inhibits EP300-mediated acetylation of histone H3 at 'Lys-9' . Plays a role in regulating the transcription of AR targets.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: ZNF451 polyclonal Antibody detects endogenous levels of ZNF451 protein.

Molecular Weight: Refer to figures

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: COASTER;dJ417I1.1

Immunogen: Recombinant protein of human ZNF451

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: