Zoledronic acid hydrate | 2653

Zoledronic acid is a third-generation bisphosphonate that inhibits the prenylation of GTPases critical to the signaling events related to osteoclast-mediated bone resorption. It displays high affinity for hydroxyapatite (Ki = 3.47 μM) and binds directly to mineralized bone where it decreases bone resorption by inhibiting osteoclast proliferation and inducing osteoclast apoptosis. At micromolar concentrations, zoledronic acid demonstrates antitumor effects in vitro against breast, prostate, and myeloma cancer cells by inducing cytostasis and prevents bone metastases through its inhibitory effects on adhesion molecules, tumor cell invasion, and angiogenesis. Zoledronic acid has been used in the treatment of osteoporosis, Paget’s disease, metastatic bone disease, multiple myeloma, hypercalcemia of malignancy, and skeletal-related events associated with metastatic castrate-resistant prostate cancer.

Zoledronic acid is a third-generation bisphosphonate that inhibits the prenylation of GTPases critical to the signaling events related to osteoclast-mediated bone resorption. It displays high affinity for hydroxyapatite (Ki = 3.47 μM) and binds directly to mineralized bone where it decreases bone resorption by inhibiting osteoclast proliferation and inducing osteoclast apoptosis. At micromolar concentrations, zoledronic acid demonstrates antitumor effects in vitro against breast, prostate, and myeloma cancer cells by inducing cytostasis and prevents bone metastases through its inhibitory effects on adhesion molecules, tumor cell invasion, and angiogenesis.

2653 | Zoledronic acid hydrate DataSheet

Alternate Name/Synonyms: (1-hydroxy-2-(1H-imidazol-1-yl)ethane-1,1-diyl)diphosphonic acid; NDC-zoledronate; zoledronate; Zometa; Reclast ; CGP 42446; CGP42446A; ZOL 446

Appearance: Crystaline solid

Formulation: N/A

CAS Number: 165800-06-6

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₅H₁₂N₂O₈P₂

Molecular Weight: 290.1

Cell-Permeable?: Yes

Purity: ≥98%

Solubilities: PBS (~ 1.6 mg/ml)

Handling: Protect from air and moisture

Country of Origin: USA

Tag Line: A specific inhibitor of osteoclast-mediated bone resporption

MDL Number: MFCD08448695

PubChem CID: 121586

SMILES: C1=CN(C=N1)CC(O)(P(=O)(O)O)P(=O)(O)O.O

InChi: InChI=1S/C5H10N2O7P2.H2O/c8-5(15(9,10)11,16(12,13)14)3-7-2-1-6-4-7;/h1-2,4,8H,3H2,(H2,9,10,11)(H2,12,13,14);1H2

InChi Key: FUXFIVRTGHOMSO-UHFFFAOYSA-N