Zosuquidar trihydrochloride | 9488

Zosuquidar is a potent P-glycoprotein (P-gp) inhibitor (Kd = 79 nM). Zosuquidar binds with high affinity to P-glycoprotein and inhibits P-glycoprotein-mediated multidrug resistance (MDR). Restores doxorubicin (Cat. No. 1527) sensitivity in P-gp-expressing multidrug (MDR) resistant cancer cell lines.

Zosuquidar is a potent P-glycoprotein (P-gp) inhibitor (Kd = 79 nM). Zosuquidar binds with high affinity to P-glycoprotein and inhibits P-glycoprotein-mediated multidrug resistance (MDR). Restores doxorubicin (Cat. No. 1527) sensitivity in P-gp-expressing multidrug (MDR) resistant cancer cell lines.

9488 | Zosuquidar trihydrochloride DataSheet

Alternate Name/Synonyms: (αR)-4-[(1aα,6α,10bα)-1,1-Difluoro-1,1a,6,10b-tetrahydrodibenzo[a,e]cyclopropa[c]cyclohepten-6-yl]-α-[(5-quinolinyloxy)methyl]-1-piperazineethanol trihydrochloride; LY335979

Appearance: White solid

Formulation: N/A

CAS Number: 167465-36-3

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: N/A

Molecular Formula: C₃₂H₃₁FN₃O.3HCl

Molecular Weight: 636.99

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (>25 mg/ml)

Handling: Protect from air and moisture

Country of Origin: USA

Tag Line: A potent P-glycoprotein (P-gp) inhibitor

MDL Number: MFCD00942300

PubChem CID: 153997

SMILES: C1CN(CCN1CC(COC2=CC=CC3=C2C=CC=N3)O)C4C5=CC=CC=C5C6C(C6(F)F)C7=CC=CC=C47.Cl.Cl.Cl

InChi: InChI=1S/C32H31F2N3O2.3ClH/c33-32(34)29-22-7-1-3-9-24(22)31(25-10-4-2-8-23(25)30(29)32)37-17-15-36(16-18-37)19-21(38)20-39-28-13-5-12-27-26(28)11-6-14-35-27;;;/h1-14,21,29-31,38H,15-20H2;3*1H/t21-,29-,30+,31?;;;/m1.../s1

InChi Key: ZPFVQKPWGDRLHL-ZLYBXYBFSA-N