2'-Deoxy-6-thioguanosine | 2828

6-Thio-dG induces telomere dysfunction in telomerase-positive human cancer cells and hTERT-expressing human fubroblasts, but not in telomerase-negative cells. Treatment with 6-thio-dG results in rapid cell death for a wide variety of cancer cells, whereas normal human fibroblasts and human colonic epithelial cells are mostly unaffected.

6-Thio-dG induces telomere dysfunction in telomerase-positive human cancer cells and hTERT-expressing human fubroblasts, but not in telomerase-negative cells. Treatment with 6-thio-dG results in rapid cell death for a wide variety of cancer cells, whereas normal human fibroblasts and human colonic epithelial cells are mostly unaffected.

2828 | 2'-Deoxy-6-thioguanosine DataSheet

Alternate Name/Synonyms: 2'-Deoxy-6-thio-D-guanosine;6-Thio-2'-deoxyguanosine; 6-thio-DG

Appearance: White to off-white solid

Formulation: N/A

CAS Number: 789-61-7

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: M

Molecular Formula: C₁₀H₁₃N₅O₃S

Molecular Weight: 283.31

Cell-Permeable?: yes

Purity: ≥97% by HPLC

Solubilities: DMSO:H₂O (1:2) (50 mM)

Handling: Protect from air and moisture

Country of Origin: USA

Tag Line: An anticancer agent

MDL Number: MFCD00672275

PubChem CID: 3000603

SMILES: C1C(C(OC1N2C=NC3=C2NC(=NC3=S)N)CO)O

InChi: InChI=1S/C10H13N5O3S/c11-10-13-8-7(9(19)14-10)12-3-15(8)6-1-4(17)5(2-16)18-6/h3-6,16-17H,1-2H2,(H3,11,13,14,19)/t4-,5+,6+/m0/s1

InChi Key: SCVJRXQHFJXZFZ-KVQBGUIXSA-N