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6282BP | BRD3 Blocking Peptide DataSheetAntibody Target: BRD3Accession #: Q15059Gene ID: 8019Appearance: Colorless liquidConcentration: 0.5 mg/mlFormulation: 50 µg (0.5 mg/ml) in phosphate buffered...

The acetylation of histone lysine residues plays a crucial role in the epigenetic regulation of gene transcription. A bromodomain is a protein domain that recognizes acetylated lysine residues such...

6665 | BRD3-BD1 Antibody DataSheet

6662 | BRD3-BD2 Antibody DataSheet

The acetylation of histone lysine residues plays a crucial role in the epigenetic regulation of gene transcription. A bromodomain is a protein domain that recognizes acetylated lysine residues such...

The acetylation of histone lysine residues plays a crucial role in the epigenetic regulation of gene transcription. A bromodomain is a protein domain that recognizes acetylated lysine residues such...

6283BP | BRD4 Blocking Peptide DataSheetAntibody Target: BRD4Accession #: O60885Gene ID: 23476Appearance: Colorless liquidConcentration: 0.5 mg/mlFormulation: In phosphate-buffered saline (PBS)...

The acetylation of histone lysine residues plays a crucial role in the epigenetic regulation of gene transcription. A bromodomain is a protein domain that recognizes acetylated lysine residues such...

BRD4770 is a selective inhibitor of the histone methyltransferase G9a (also named euchromatin histone methyltransferase 2 (EHMT2). BRD4770 blocks lysine residue 9 methylation of histone H3 without...

BRD6929 is a benzamide-based brain-penetrant inhibitor of Histone deacetylases HDAC1 and HDAC2. It increases histone acetylation and inhibits HDAC1 and HDAC2 with an IC₅₀ of 1 nM and 8 nM...

BRD 7116 is a selective inhibitor of leukemia stem cell (LSC) activity (EC₅₀ value of 200 nM). BRD 7116 does not affect normal hematopoietic stem cells or AML cell lines (EC₅₀s = 20 µM).BRD 7116 is a...

3506 | BRD8 Antibody DataSheet

3506BP | BRD8 Blocking Peptide DataSheetAntibody Target: BRD8Accession #: Q5TLG7Gene ID: 291691Appearance: Colorless liquidConcentration: 0.5 mg/mlFormulation: 50 µg (0.5 mg/ml) in phosphate buffered...

BRD9539 is a specific inhibitor of euchromatin histone methyltransferase G9a (EHMT2). EHMT2 catalyzes the methylation of lysine 9 on histone H3. BRD9539 inhibits EHMT2 with an IC₅₀ of 6.3 μM. It also...

6642 | BRDT Antibody DataSheet

K306 | BrdU Cell Proliferation Assay Kit DataSheet

Breeze DNA Polymerase | M1148

Breeze Pcr Mix | M1134

Breeze Pcr Mix-Dye | M1135

Brefeldin A has been shown to induce apoptosis in human tumor cells through caspase activation. It has also been shown to block translocation of proteins from the endoplasmic reticulum to the Golgi...

Brequinar sodium is a potent and selective dihydroorotate dehydrogenase (DHODH) inhibitor (IC50 = ~20 nM). Blocks de novo pyrimidine biosynthesis. Displays minimal inhibition against a panel of >400...

3739 | BRG1 Antibody DataSheet

Briciclib is a small molecule that suppresses cyclin D1 accumulation in cancer cells. Cyclin D, a member of the cyclin family of cell cycle regulators, plays a key role in cell cycle division and is...

Brigatinib is a highly potent and selective ALK (anaplastic lymphoma kinase) inhibitor. Potentially useful for the treatment of non-small cell lung cancer (NSCLC).Brigatinib is a highly potent and...

Brigantinib alalog is an analog of Brigatinib (AP26113) (Cat.No. 9675), a phosphine oxide-containing ALK inhibitor. It potently inhibits ALK (IC₅₀ = 0.07 nM) over IGF-1R and InsR (IC₅₀s = 3.2 and 100...

The detergent Brij™ 35 is a nonionic polyoxyethylene surfactant frequently used as a component of cell lysis buffers or a surfactant in various HPLC applications. The MegaPure® detergent solutions...

Luciferin is a substrate for luciferase. It is oxidised by luciferase to generate light in the presence of ATP. Luciferase is used as a reporter gene linked to a promoter of interest. Luciferin is...

’s BriteRuler™ 1 kb DNA Ladder is a ready-to-use formulation containing bromophenol blue as the tracking dye and is suitable for sizing linear double-stranded DNA fragments from 250 bp to 10 kb. The...

’s BriteRuler™ Pre-stained Protein Ladder is a ready-to-use formulation which does not require boiling, contains 10 pre-stained proteins covering a wide range of molecular weights (10-180 kDa) and...

Brivanib Alaninate is an ATP-competitive inhibitor of VEGFR2 with (IC₅₀ = 25 nM). Displays potent antineoplastic activity.Brivanib Alaninate is an ATP-competitive inhibitor of VEGFR2 with (IC₅₀ = 25...

Brivanib is a potent, ATP-competitive inhibitor against human Flk-1 (VEGFR-2) and mouse Flk-1 with IC₅₀ of 25 nM and 89 nM, respectively. Brivanib also inhibits VEGFR-1 and FGFR-1 with IC₅₀ values of...

3847 | Brk Antibody DataSheet

3847BP | Brk Blocking Peptide DataSheetAntibody Target: BrkAccession #: EAW75262Gene ID: 5753Appearance: Colorless liquidConcentration: 0.5 mg/mlFormulation: 50 µg (0.5 mg/ml) in phosphate buffered...

BRK is another member of the non-receptor tyrosine kinases (PTKs) that contains an amino terminal SH3 and SH2 domains as well as the catalytic domain (1). Although BRK shows strongest sequence...

BRL-15572 hydrochloride is a selective h5-HT1D antagonist, displaying 60-fold selectivity over h5-HT1B. It displays little or no affinity for a range of other receptor types.BRL-15572 hydrochloride...

The breast cancer metastasis suppressor-1 (BRMS1) is a candidate metastasis-suppressing gene and has been shown to potentially inhibit tumor progression. BRMS1 transcriptional repressor and anoikis...

Bromocriptine is a potent Cytochrome P450 3A inhibitor (~770 nM, see cat#K702). It also acts as a dopamine receptor agonist via the D2 receptor (Ki = 2.5 nM). As a result, it is used in combination...

Cell-permeable. A potent and highly specific inhibitor for the BET (bromodomain and extra-terminal) family of bromodomains. (+)-JQ1 binds to BRD4 bromodomains 1 and 2 with Kd values of ~ 50 and 90...

BrdT is similar to the RING3 protein family. It possesses 2 bromodomain motifs and a PEST sequence. The bromodomain is found in proteins that regulate transcription. BrdT drives a meiotic and...

BrdT is similar to the RING3 protein family. It possesses 2 bromodomain motifs and a PEST sequence. The bromodomain is found in proteins that regulate transcription. BrdT drives a meiotic and...

BrD4 protein is homologous to the murine protein MCAP, which associates with chromosomes during mitosis, and to the human RING3 protein. Each of these proteins contains two bromodomains, a conserved...

BrD4 protein is homologous to the murine protein MCAP, which associates with chromosomes during mitosis, and to the human RING3 protein. Each of these proteins contains two bromodomains, a conserved...

Bromosporine is a broad spectrum bromodomain inhibitor (IC₅₀s = 0.41 µM, 0.29 µM, 0.122 µM and 0.017 µM for BRD2, BRD4, BRD9 and CECR2, respectively). At 1 µM, Bromosporine accelerates FRAP recovery...

Brusatol is a quassinoid isolated from the Brucea javanica plant that has recently been shown to inhibit Nrf2 signaling, reduce tumor burden, and ameliorate chemoresistance in both in vitro and in...

Bryostatin 1 is a naturally occurring macrocyclic lactone that binds to and activates protein kinase C, but its biological effects differ greatly from those induced by other protein kinase C...

BS-181 dihydrochloride is a potent and selective CDK7 inhibitor (IC₅₀ = 21 nM). It displays >40-fold selectivity for CDK7 over others CDKs. Promotes cell cycle arrest and apoptosis in a range of...

KEY FEATURES: • Amine-reactive; has a non-cleavable spacer with arm length of 11.4 Å • Water-soluble • Membrane-impermeable APPLICATIONS: • Crosslinking of proteins through reaction with...

10 mg/ml BSA in PBS. 2221-BSA | BSA (10 mg/ml BSA in PBS) DataSheet Sort Name:BSA (10 mg/ml BSA in PBS) Label Name: BSA (10 mg/ml BSA in PBS) Taglines: 10 mg/ml BSA solution for multiple applications...

BSA makes up approximately 60% of all proteins in animal serum. It is commonly used in cell culture protocols, particularly when protein supplementation is necessary and the other components of serum...

5998 | BSA Antibody DataSheet

BSJ-03-123 is a potent, CDK6-selective small-molecule degrader (PROTAC). BSJ-03-123 causes a pronounced anti-proliferative effect in CDK6-dependent AML cell lines by inducing a G1 cell-cycle arrest...

Bst DNA Polymerase, Large Fragment is a DNA polymerase from Bacillus stearothermophilus that is modified so that it retains its 5’→ 3’ DNA polymerase activity while lacking the intrinsic 5’→ 3’...

Bst Nickase is a nicking endonuclease from Bacillus stearothermophilus that cleaves one DNA strand of a double-stranded DNA substrate. M1235 | Bst Nickase DataSheetSort Name: Bst NickaseLabel Name:...

Bsu DNA Polymerase, Large Fragment is from Bacillus subtilis and is modified so that it retains its 5’→ 3’ DNA polymerase activity with its 5’→ 3’ exonuclease domain removed. This DNA Polymerase...

BT-13 is a potent and selective agonist of RET tyrosine kinase and its downstream signaling cascades. BT-13 promotes neurite growth from sensory neurons in vitro and attenuates experimental...

BT2 is an inhibitor of the mitochondrial branched-chain a-ketoacid dehydrogenase complex kinase (BCKDC) - IC50 = 3.19 µM. Inhibition of this kinase has been shown to reduce levels of branched-chain...

Human Betacellulin (BTC) is a potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells. The effects of betacellulin are probably mediated by the egf receptor and other...

3743 | BTF Antibody DataSheet

BTK inhibitor II is a potent Bruton's tyrosine kinase (BTK) inhibitor.BTK inhibitor II is a potent Bruton's tyrosine kinase (BTK) inhibitor.B2453 | BTK Inhibitor II DataSheetAlternate Name/Synonyms:...

CNX-774 is a potent, irreversible BTK inhibitor (IC₅₀ < 1 nM). CNX-774 is highly selective for BTK, and forms a ligand-directed covalent bond with the Cys-481 residue within the ATP binding site of...

A potent and highly selective small-molecule inhibitor of Bruton's tyrosine kinase (BTK) (IC₅₀ = 0.5 nM) with potential antineoplastic activity. It.binds to and irreversibly inhibits BTK activity,...

A1082 | BTLA Polyclonal Antibody DataSheet

BTZ043 is a decaprenyl-phosphoribose-epimerase (DprE1) inhibitor acting as a new antimycobacterial agent that kill Mycobacterium tuberculosis (TB). It displays nanomolar bactericidal activity against...

Budesonide is a glucocorticoid steroid that activates the glucorcorticoid receptor (EC₅₀ = 12.4 nM). Like other glucocorticoids, budesonide reduces inflammation and has utility in inflammatory...

Bufalin is cardioactive steroid that exhibits a variety of biological activities, such as cardiotonic, anaesthetic, blood pressure stimulatory, respiratory and antineoplastic effects. Acts as a...

Beta-Lactamases (βLs), are hydrolases expressed in Gram-positive and Gram-negative bacteria. When those bacteria encounter β-lactam antibiotics which contain the four atom ring-structure, they...

Busulfan is a bifunctional alkylating agent, having a selective immunosuppressive effect on bone marrow. Busulfan causes DNA damage by cross-linking DNA and proteins. Causes double-base lesions...

Butenafine is a potent antifungal agent that has broad-spectrum activity against 87 strains of dermatophytes. Butenafine works by inhibiting the synthesis of sterols by inhibiting squalene epoxidase,...

Butyrolactone 3 is an inhibitor of histone acetyltransferase (HAT) Gcn5. Gcn5 acetylates histones H2B and H3. Butyrolactone 3 inhibits Gcn5 with an IC₅₀ value of 100 μM. It has an affinity to the...

Cell permeable. A potent and selective inhibitor of the cyclin-dependent kinases CDK1/cyclin B, CDK2 and CDK5. Inhibits cell cycle progression at the G1/S and G2/M transitions. BLI is an important...

K516 | Butyrylcholinesterase Activity Kit Colorimetric DataSheet

BV6 is a selective inhibitor of IAP proteinsBV6 is a selective inhibitor of IAP proteinsB1332 | BV6 DataSheetAlternate Name/Synonyms:...

BVT 948 is a noncompetitive, cell-permeable inhibitor of protein tyrosine phosphatases (PTP; IC₅₀s = 0.09-1.7 µM). displays irreversible inhibition through catalysis of the hydrogen...

BX-320 is an inhibitor of 3-phosphoinositide-dependent kinase-1 (PDK1). The phosphoinositide 3-kinase/PDK1/Akt signaling pathway plays an important role in cancer cell growth, survival and...

BX-471 is a potent and selective non-peptide CCR1 antagonist with a Ki of 1 nM; displays 250-fold selectivity for CCR1 over CCR2, CCR5 and CXCR4.BX-471 is a potent and selective non-peptide CCR1...

BX-517, also known as PDK1 inhibitor2, is a potent and selective PDK1 inhibitor that binds to the ATP binding pocket.BX-517, also known as PDK1 inhibitor2, is a potent and selective PDK1 inhibitor...

BX-912 is a potent and selective inhibitor of 3-phosphoinositide-dependent kinase 1 (PDK1) with IC50 value of 26nM. BX-912 has shown 9-fold selectivity for PDK1 relative to PKA and 105-fold...

BX795 is a potent and selective dual inhibitor of TBK1/PDK1 BX795 is a potent and selective dual inhibitor of TBK1/PDK1 B1766 | BX795 DataSheetAlternate Name/Synonyms: BX795; BX 795; BX795;...

CK-666 is a potent, selective and reversible inhibitor of ARP2/3 complex (actin related proteins 2 and 3) with an IC₅₀ = 4 µM for human ARP2/3. Blocks actin nucleation and radically alters...

Murine C-10 is a member of the C-C chemokine family of proteins related to macrophage inflammatory protein-1 (MIP-1). The recombinant murine C-10 is a 10.7 kDa protein containing 95 amino acid...

C-DIM 12 activates the orphan nuclear receptor Nurr1 and inhibits bladder cancer growth. Nurr1 is a suppressor of NF-kB-related neuroinflammatory genes in microglia and astrocytes and C-DIM 12...

3058 | c-FLIP Antibody DataSheet

3058BP | c-FLIP Blocking Peptide DataSheetAntibody Target: c-FLIP Accession #: O15519Gene ID: 8837Appearance: Colorless liquidConcentration: 0.2 mg/mlFormulation: 50µg (0.2 mg/ml) in phosphate...

c-Fos Transcription Factor Activity Assay Kit (Colorimetric) | K2100-100Description: Activator protein-1 (aka activating protein 1, AP-1) is a critical transcription factor that plays a central role...

c-Jun is a component of the transcription factor AP-1 that binds and activates transcription at TRE/AP-1 elements. The transcriptional activity of c-Jun is regulated by phosphorylation at Ser63 and...

c-Jun is a component of the transcription factor AP-1 that binds and activates transcription at TRE/AP-1 elements. The transcriptional activity of c-Jun is regulated by phosphorylation at Ser63 and...

K4198 | c-jun Human Elisa Kit DataSheet

c-Jun Transcription Factor Activity Assay Kit (Colorimetric) | K2097-100Description: Activator protein-1 (aka activating protein 1, AP-1) is a critical transcription factor that plays a central role...

6777 | C-Kit/CD117 Antibody (NT) DataSheet

E4351 | c-MET Human Elisa Kit DataSheet

3995 | C-Myc Antibody DataSheet

K4204 | c-myc Human Elisa Kit DataSheet

3103 | C-Peptide Antibody (Clone HCP-B2) DataSheet

3277 | C-Peptide Antibody DataSheet

3277BP | C-Peptide Blocking Peptide DataSheetAntibody Target: C-Peptide Accession #: N/AGene ID: N/AAppearance: Colorless liquidConcentration: 0.2 mg/mlFormulation: 50 µg (0.5 mg/ml) in phosphate...

E4701 | C-Peptide Elisa Kit DataSheet

C-Peptide human/mouse/rat EIA Kit | K4757

E4289 | C-Reactive Protein CRP Human Elisa Kit DataSheet

C-reactive protein (CRP) is a biomarker for inflammation in the human body. The elevation of CRP has also been linked to pathophysiology of atherosclerosis and risk to heart disease. In more than 30...

A1208 | C-reactive/CRP Monoclonal Antibody DataSheet