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A Hsp90 inhibitor. NVP-AUY922 has excellent potency against Hsp90 in a fluorescence polarization binding assay with an IC₅₀ of 21 nmol/L against the β-isoform and of 13 nmol/L for the α-isoform...

NVP-BEP800 is a potent oral inhibitor of Hsp90β (IC₅₀ = 58 nM). Displays strong anti-proliferative activity against various tumor cell lines and primary tumors in vitro and in vivo at well-tolerated...

NVP-BGJ398 is a potent and selective, pan-FGFR kinase inhibitor. It inhibits the proliferation of various FGFR-dependent cell lines at nano-molar concentrations including breast and lung cancers...

A potent, selective small-molecule inhibitor of the receptor tyrosine kinase EphB4 (ED₅₀ = 25 nM). Displays selectivity for EphB4 over >40 other kinases in vitro, including FGFR3. NVP-BHG712 blocks...

NVP-BKM120 is a potent inhibitor of class I PI3K isoforms; potently blocks both p110α (IC₅₀ = 52 nM) and p110β (IC₅₀ = 166 nM) in vitro. It is much less effective against the class III PI3K Vps34 and...

NVP-BSK805 is a potent and selective ATP-competitive inhibitor of JAK2 (IC₅₀ = 0.5 nM,). It displays >20-fold selectivity towards JAK1, JAK3 and TYK2.NVP-BSK805 is a potent and selective...

A potent and selective ALK (anaplastic lymphoma kinase) inhibitor that blocked the growth of ALCL (anaplastic large cell lymphoma)-derived and ALK-dependent cell lines with IC₅₀ = 2-10 nM. NVP-TAE684...

NVS-SM1, also known as LMI070, is a highly potent, selective small molecule SMN2 splicing modulator with potential for treating spinal muscular atrophy. It works by increasing the amount of...

NXY-059 is a free radical trapping neuroprotectant. Displays neuroprotection in several animal models of acute ischemic stroke.NXY-059 is a free radical trapping neuroprotectant. Displays...

Nylon syringe filters provide a universal application for analytical procedures. It is naturally hydrophilic, high protein binding and high dirt loading capability of Nylon are natural advantages...

Nylon syringe filters provide a universal application for analytical procedures. It is naturally hydrophilic, high protein binding and high dirt loading capability of Nylon are natural advantages...

Nylon syringe filters provide a universal application for analytical procedures. It is naturally hydrophilic, high protein binding and high dirt loading capability of Nylon are natural advantages...

Nylon syringe filters provide a universal application for analytical procedures. It is naturally hydrophilic, high protein binding and high dirt loading capability of Nylon are natural advantages...

Nylon syringe filters provide a universal application for analytical procedures. It is naturally hydrophilic, high protein binding and high dirt loading capability of Nylon are natural advantages...

Nylon syringe filters provide a universal application for analytical procedures. It is naturally hydrophilic, high protein binding and high dirt loading capability of Nylon are natural advantages...

Nylon syringe filters provide a universal application for analytical procedures. It is naturally hydrophilic, high protein binding and high dirt loading capability of Nylon are natural advantages...

Nylon syringe filters provide a universal application for analytical procedures. It is naturally hydrophilic, high protein binding and high dirt loading capability of Nylon are natural advantages...

Nylon syringe filters provide a universal application for analytical procedures. It is naturally hydrophilic, high protein binding and high dirt loading capability of Nylon are natural advantages...

Nylon syringe filters provide a universal application for analytical procedures. It is naturally hydrophilic, high protein binding and high dirt loading capability of Nylon are natural advantages...

Nylon syringe filters provide a universal application for analytical procedures. It is naturally hydrophilic, high protein binding and high dirt loading capability of Nylon are natural advantages...

Nylon syringe filters provide a universal application for analytical procedures. It is naturally hydrophilic, high protein binding and high dirt loading capability of Nylon are natural advantages...

Nylon syringe filters provide a universal application for analytical procedures. It is naturally hydrophilic, high protein binding and high dirt loading capability of Nylon are natural advantages...

Nylon syringe filters provide a universal application for analytical procedures. It is naturally hydrophilic, high protein binding and high dirt loading capability of Nylon are natural advantages...

Nylon syringe filters provide a universal application for analytical procedures. It is naturally hydrophilic, high protein binding and high dirt loading capability of Nylon are natural advantages...

Nylon syringe filters provide a universal application for analytical procedures. It is naturally hydrophilic, high protein binding and high dirt loading capability of Nylon are natural advantages...

Nylon syringe filters provide a universal application for analytical procedures. It is naturally hydrophilic, high protein binding and high dirt loading capability of Nylon are natural advantages...

Nylon syringe filters provide a universal application for analytical procedures. It is naturally hydrophilic, high protein binding and high dirt loading capability of Nylon are natural advantages...

Nylon syringe filters provide a universal application for analytical procedures. It is naturally hydrophilic, high protein binding and high dirt loading capability of Nylon are natural advantages...

Nylon syringe filters provide a universal application for analytical procedures. It is naturally hydrophilic, high protein binding and high dirt loading capability of Nylon are natural advantages...

Nylon syringe filters provide a universal application for analytical procedures. It is naturally hydrophilic, high protein binding and high dirt loading capability of Nylon are natural advantages. ...

Nylon syringe filters provide a universal application for analytical procedures. It is naturally hydrophilic, high protein binding and high dirt loading capability of Nylon are natural advantages. ...

Nylon syringe filters provide a universal application for analytical procedures. It is naturally hydrophilic, high protein binding and high dirt loading capability of Nylon are natural advantages. ...

Nylon syringe filters provide a universal application for analytical procedures. It is naturally hydrophilic, high protein binding and high dirt loading capability of Nylon are natural advantages. ...

Nylon syringe filters provide a universal application for analytical procedures. It is naturally hydrophilic, high protein binding and high dirt loading capability of Nylon are natural advantages. ...

Nylon syringe filters provide a universal application for analytical procedures. It is naturally hydrophilic, high protein binding and high dirt loading capability of Nylon are natural advantages...

Nystatin is a polyene antifungal antibiotic produced by Streptomyces noursei. Nystatin acts by binding to ergosterols in fungal cell membranes, increasing permeability of the membrane, and creating...

K822 | Nα-Nicotinamide Methyltransferase NNMT Inhibitor Screening Assay Kit DataSheet

O-Benzyl-L-serine (BenSer) is an inhibitor of the glutamine transporter ASCT2. BenSer significantly reduces both leucine and glutamine transport in melanoma cells, leading to inhibition of mTORC1...

O-Propargyl-puromycin (OPP) is cell-permeable alkyne analog of the protein synthesis inhibitor puromycin (Cat. No. 1860) that efficiently incorporates into newly translated proteins in complete...

O4I1 is potent inducer of Oct3/4 (Octamer–binding transcription factor) and enhances the expression and stabilization of Oct 3 & 4 in neonatal fibroblasts. It also increases the transcriptional...

O4I2 is a potent Oct3/4 inducer in various human cell lines including human fibroblasts. O4I2 might be a useful tool for induction of pluripotency in somatic cells.O4I2 is a potent Oct3/4 inducer in...

OAC1 is an Oct4-activating compound that activates expression through the Oct4 gene promoter. In cells expressing Oct4 with Sox2, Klf4, and c-Myc, OAC1 (1 μM) enhances reprogramming efficiency by...

OAC2 is an Oct4-activating compound that activates expression through the Oct4 gene promoter. In cells expressing Oct4 with Sox2, Klf4, and c-Myc, OAC2 (1 μM) enhances reprogramming efficiency by...

OAC3 (Oct4-activating compound3) is an activator of octamer-binding transcription factor 4 (Oct4). Oct4 is an important regulator of embryonic stem cells pluripotency. It is used to generate induced...

OATD-01 is a small molecule inhibitor of acidic mammalian chitinase (AMCase) (IC50 = 9 nM) and chitotriosidase (CHIT1) (IC50 = 26 nM). OATD-01 displays robust anti-fibrotic activity in multiple...

Obestatin decreases food intake and body weight in rodents. Obestatin also counteracts ghrelin’s effect by decelerating gastric emptying and decreasing intestinal contractility.Obestatin decreases...

Obestatin human/mouse/rat EIA Kit | K4759

Obeticholic acid is a derivative of cholic acid which acts as a potent and selective FXR (Farnesoid X receptor) agonist (EC₅₀ = 99 nM) displaying anticholeretic activity in an in vivo rat model of...

3342 | Oct-1 Antibody DataSheet

Antibody Target: 40452Accession #: P14859Gene ID: 5451Appearance: Colorless liquidConcentration: 0.2 mg/mlFormulation: 50 µg (0.2 mg/ml) in phosphate buffered saline (PBS), pH 7.2, containing 0.1%...

3575 | Oct-2 Antibody DataSheet

3575BP | Oct-2 Blocking Peptide DataSheetAntibody Target: Oct-2Accession #: AAA59978Gene ID: 5452Appearance: Colorless liquidConcentration: 0.5 mg/mlFormulation: 50 µg (0.5 mg/ml) in phosphate...

3576 | Oct-4 Antibody DataSheet

3576BP | Oct-4 Blocking Peptide DataSheetAntibody Target: 40455Accession #: P20263Gene ID: 18999Appearance: Colorless liquidConcentration: 0.5 mg/mlFormulation: 50 µg (0.5 mg/ml) in phosphate...

E4336 | Oct4 Human Transcription Factor Activity Assay Kit DataSheet

6765 | OCT4 (OCT3) Antibody DataSheet

Octreotide is the acetate salt of a synthetic long-acting cyclic octapeptide with pharmacologic properties mimicking those of the natural hormone somatostatin. Octreotide is a more potent inhibitor...

A non-ionic detergent useful for solubilizing membrane-bound proteins in their native state (CMC = 9 mM).Octyl-β-D-thioglucopyranoside is a non-ionic detergent useful for solubilizing membrane-bound...

Odanacatib is a potent, selective, and neutral inhibitor of cathepsin KOdanacatib is a potent, selective, and neutral inhibitor of cathepsin KB1617 | Odanacatib DataSheetAlternate Name/Synonyms:...

ODM-201 is a new-generation, potent and selective androgen receptor (AR) antagonist (Ki = 11 nM). In AR overexpressing HS-HEK293 cells, ODM-201 inhibits the androgen-induced nuclear translocation of...

A specific inhibitor OF soluble guanylyl cyclase (sGC) (IC50 = 20 nM). ODQ is a useful and selective tool to elucidate the physiological importance of the NO-cGMP pathway.ODQ is a specific inhibitor...

OF-1 is a selective BRPF1B and BRPF2 bromodomain inhibitor (Kd values are 100 and 500 nM respectively). OF-1 displays 39-fold selectivity for BRPF1B and BRPF2 over BRD4. It increases thermal...

Ofloxacin (Hoe-280) is a fluoroquinolone antibacterial agent used for the treatment of bacterial infections in many parts of the body, including the respiratory tract, kidney, skin, soft tissue, and...

OG-L002 is a potent and specific inhibitor of Lysine Specific Demethylase-1(LSD-1) (IC₅₀ of 20 nM). Displays 36- and 69-fold selectivity over MAO-B and MAO-A, respectively. It potently represses...

OGG1 Inhibitor O8 is a potent inhibitor of 8-Oxoguanine DNA Glycosylase-1 (OGG1).OGG1 Inhibitor O8 is a potent inhibitor of 8-Oxoguanine DNA Glycosylase-1 (OGG1).B2235 | OGG1 inhibitor O8...

OICR-9429 is a small-molecule inhibitor of the WDR5-MLL interaction that effectively stops the growth of breast cancer cell lines driven by p53 gene mutation. It also stops the growth of subtype of...

A Potent inhibitor of protein phosphatases 1 and 2A in numerous cell types. Does not affect activity of acid phosphatase, alkaline phosphatase and tyrosine phosphatase. Non-phorbol type tumor...

An ammonium salt form of the protein phosphatase inhibitor Okadaic acid (Cat. No. 1543-025) with somewhat greater stability than the free acid when stored in organic solvents.Okadaic acid, Ammonium...

Potassium salt form of the protein phosphatase inhibitor Okadaic acid (Cat. No. 1543-025) with somewhat greater stability than the free acid when stored in organic solvents.Okadaic acid, Potassium...

Sodium salt form of the protein phosphatase inhibitor Okadaic acid (Cat. No. 1543-025) with somewhat greater stability than the free acid when stored in organic solvents.Okadaic acid, Sodium Salt is...

Olanzapine is an antipsychotic agent with anticholinergic properties. It binds to dopamine D1, D2, and D4 receptors (Kis = 31, 11, and 27 nM, respectively) as well as the serotonin (5-HT) receptor...

Cell-permeable. A highly potent and selective PARP-inhibitor with IC₅₀ values of 5 nM and 1 nM for PARP-1 and PARP-2, respectively. Olaparib displays standalone activity in BRCA-1 deficient breast...

A triterpenoid compound that exists widely in food, medicinal herbs and other plants. Displays anti-tumor, anti-inflammatory and antihyperlipidemic properties. Also displays TGR5 agonist activity...

Oligomycin is an inhibitor of mitochondrial F1F0 ATP synthase. A useful tool for decreasing cellular ATP levels. Induces autophagy. Stimulates lysosome acidification. Oligomycin protects against...

Olmutinib (BI 1482694), is a third-generation epidermal growth factor receptor (EGFR) mutation-specific tyrosine kinase inhibitor (TKI). It inhibits both EGFR activating and T790M resistance...

OLT1177 | B2358

Human Omentin is an adipocyte derived protein that counteracts obesity and related insulin resistin. Omentin is comprised of 313 amino acids and has a molecular mass of 35 kDa.4925 | Omentin human...

Omeprazole is a proton pump inhibitor (PPI). It inhibits gastric H+/K+ ATPase with an IC₅₀ of 1.1 μM. It shows competitive inhibition of cytochrome P450 enzyme CYP2C19 activity with a Ki of 2-6 μM...

ON-013100 is a cell cycle inhibitor and is potentially useful for the treatment of mantle cell lymphoma.ON-013100 is a cell cycle inhibitor and is potentially useful for the treatment of mantle cell...

ONC-201 is an orally active transcriptional inducer of Tumor necrosis factor–related apoptosis-inducing ligand (TRAIL). It induces TRAIL in a p53-independent manner at concentrations of 1.25 μM-5 μM...

ONC212 is a fluorinated imipridone analogue of ONC201. It is an activator of GPCR GPR132 and Gαq signaling, which functions as a tumor suppressor. It induces apoptosis in HPAF-II and AsPC1 cell lines...

Oncostatin M (OSM) is an important growth regulating cytokine that affects, variably, a number of tumor and normal cells. Oncostatin M exerts inhibitory effects on the growth of A375 melanoma and...

Oncostatin M (OSM) is a growth and differentiation factor that participates in the regulation of neurogenesis, osteogenesis and hematopoiesis. Produced by activated T cells, monocytes and Kaposi’s...

ONO-1078 is a novel leukotriene antagonist that inhibits and reverses human bronchial contraction induced by leukotrienes C4 and D4 and antigen in vitro. It also shows concentration dependent...

ONO4059-Analog is a structural analogue of ONO-4059 that acts as a potent and selective BTK (Bruton's tyrosine kinase) inhibitor.ONO4059-Analog is a structural analogue of ONO-4059 that acts as a...

ONO-4059 is a highly selective, orally bioavailable BTK (Bruton’s Tyrosine Kinase) inhibitor with a potency an IC₅₀ of 2.2 nM.ONO-4059 is a highly selective, orally bioavailable BTK (Bruton’s...

A potent and selective immunoproteasome inhibitor with minimal cross-reactivity for the constitutive proteasome. It selectively inhibits low–molecular mass polypeptide-7 (LMP7, encoded by Psmb8), the...

Oosporein is a di-symmetric cyclohexadienedione produced by several species of fungi. Displays toxic effects on humans as well as animal health. Also acts as an ATPase inhibitor.Oosporein is a...

5312 | OPG Antibody DataSheet

Opiates Elisa Kit | E4297

Opicapone is a potent inhibitor of catechol-O-methyltransferase (COMT). It inhibits rat peripheral COMT with ED₅₀ values below 1.4 mg/kg up to 6 h post-administration. It is approved for use as...

Oprozomib is a next generation, irreversible and selective proteasome inhibitor that displays potent anti-myeloma properties. It potently induces apoptosis in HNSCC cell lines via upregulation of...

Optovin is a reversible photoactive TRPA1 activator. It specifically activates TRPA1 (EC₅₀ = 2 μM) but not TRPV1 or TRPM8. Optovin activates human TRPA1 via structure-dependent photochemical...

Orange G Dye runs faster than Bromophenol blue dye in standard agarose gel, which allows clear visualization of small DNA fragments on the gel.2110 | Orange G Loading Buffer DataSheetSort Name: 10X...

Oral cancer-overexpressed protein 1 (ORAOV1) is found in many solid tumors, making a key contribution to the development of cancer. It is found as a key candidate oncogene in the 11q13 chromosomal...

K1432 | Orcein Stain Kit DataSheet

Orelabrutinib is a potent and irreversible Bruton's tyrosine kinase (BTK) inhibitor with potential antineoplastic activity. Orelabrutinib prevents both the activation of the B-cell antigen receptor...

Orexin-2 receptor agonist is a potent and selective selective nonpeptidic orexin2 receptor (OX2R) agonist (OX2R EC₅₀ = 0.023 μM).Orexin-2 receptor agonist is a potent and selective selective...

K468 | Org Frontier Chloroplast Isolation Kit DataSheet

Org Jade™ QRT Kit | M1179