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An irreversible inhibitor of serine proteases (such as thrombin, trypsin and chymotrypsin) and mammalian acetylcholinesterase. It causes sulfonylation of the active-site serine residues. Inhibits...

The free form of pNA can be used as a colorimetric marker and reference standard in colorimetric enzyme assays using pNA-based substrates.pNA (p-nitroaniline) is the free form of pNA that can be used...

PND-1186 is a potent FAK (Focal adhesion kinase) inhibitor (IC₅₀ = 1.5 nM) with potential antineoplastic activity. PND-1186 inhibits FAK, blocks fibronectin-stimulated FAK autophosphorylation of...

K1434 | Pneumocystis Stain Kit DataSheet

PNGase F is an amidohydrolase, which cleaves the β-aspartylglucosamine bond between the innermost GlcNAc of glycans and asparagine residues of high mannose, hybrid and complex oligosaccharides from...

PNP belongs to the PNP/MTAP phosphorylase family of proteins. This protein catalyzes the reversible phosphorolysis of ribonucleosides and 2'-deoxyribonucleosides with specificity for guanine,...

PNU-74654 is a β-catenin inhibitor (Kd = 450 nM), inhibiting its interaction with the transcription factor T cell factor 4 (Tcf4) resulting in disruption of the Wnt signaling pathway. Treatment of...

PODXL, also known as Podocalyxin, is a heavily glycosylated transmembrane sialoprotein in the CD34 and endoglycan family. This protein involved in the regulation of both adhesion and cell morphology...

Podophyllotoxin is a potent inhibitor of microtubule assembly and DNA topoisomerase II. Displays anticancer properties. Also antiviral and antihelminthic.Podophyllotoxin is a potent inhibitor of...

Poly(A) Polymerase catalyses the template independent addition of adenosine residues onto the 3’ ends of polyribonucleotidesM1215 | Poly(A) Polymerase Yeast DataSheetSort Name: Poly(A) Polymerase...

Poly(I:C) is a double-stranded homopolymer of polyinosinic acid and polycytidylic acid. Transfection of Poly(I:C) (1 μg/ml) into NIT 1 cells has been used as a model of intracellular double-stranded...

Polydatin | B3380Description: Polydatin is a monocrystalline compound isolated from the root and rhizome of Polygonum cuspidatum Sieb. et Zucc. (Polygonaceae). It displays antioxidant and...

PES syringe filters are applicable to sterile filtering of protein solutions, tissue culture media filtration, and tissue culture additive filtration. These filters are hydrophilic in nature and they...

PES syringe filters are applicable to sterile filtering of protein solutions, tissue culture media filtration, and tissue culture additive filtration. These filters are hydrophilic in nature and they...

PES syringe filters are applicable to sterile filtering of protein solutions, tissue culture media filtration, and tissue culture additive filtration. These filters are hydrophilic in nature and they...

PES syringe filters are applicable to sterile filtering of protein solutions, tissue culture media filtration, and tissue culture additive filtration. These filters are hydrophilic in nature and they...

PES syringe filters are applicable to sterile filtering of protein solutions, tissue culture media filtration, and tissue culture additive filtration. These filters are hydrophilic in nature and they...

Polymyxin B sulfate is a polypeptide antibiotic and is composed of polymyxins B1, B2, and B3 with fractions B1 and B2 comprising the majority of the mixture. Polymyxin B targets and alters...

Polypropylene (PP) syringe filters are designed for aqueous or organic solutions that have high levels of debris and for difficult-to-filter solutions. It's a hydrophilic membrane with a wide range...

Polypropylene (PP) syringe filters are designed for aqueous or organic solutions that have high levels of debris and for difficult-to-filter solutions. It's a hydrophilic membrane with a wide range...

Polypropylene (PP) syringe filters are designed for aqueous or organic solutions that have high levels of debris and for difficult-to-filter solutions. It's a hydrophilic membrane with a wide range...

Polypropylene (PP) syringe filters are designed for aqueous or organic solutions that have high levels of debris and for difficult-to-filter solutions. It's a hydrophilic membrane with a wide range...

Polypropylene (PP) syringe filters are designed for aqueous or organic solutions that have high levels of debris and for difficult-to-filter solutions. It's a hydrophilic membrane with a wide range...

Polypropylene (PP) syringe filters are designed for aqueous or organic solutions that have high levels of debris and for difficult-to-filter solutions. It's a hydrophilic membrane with a wide range...

Polypropylene (PP) syringe filters are designed for aqueous or organic solutions that have high levels of debris and for difficult-to-filter solutions. It's a hydrophilic membrane with a wide range...

Polypropylene (PP) syringe filters are designed for aqueous or organic solutions that have high levels of debris and for difficult-to-filter solutions. It's a hydrophilic membrane with a wide range...

Polypropylene (PP) syringe filters are designed for aqueous or organic solutions that have high levels of debris and for difficult-to-filter solutions. It's a hydrophilic membrane with a wide range...

Polypropylene (PP) syringe filters are designed for aqueous or organic solutions that have high levels of debris and for difficult-to-filter solutions. It's a hydrophilic membrane with a wide range...

Polypropylene (PP) syringe filters are designed for aqueous or organic solutions that have high levels of debris and for difficult-to-filter solutions. It's a hydrophilic membrane with a wide range...

Polypropylene (PP) syringe filters are designed for aqueous or organic solutions that have high levels of debris and for difficult-to-filter solutions. It's a hydrophilic membrane with a wide range...

Polypropylene (PP) syringe filters are designed for aqueous or organic solutions that have high levels of debris and for difficult-to-filter solutions. It's a hydrophilic membrane with a wide range...

Polypropylene (PP) syringe filters are designed for aqueous or organic solutions that have high levels of debris and for difficult-to-filter solutions. It's a hydrophilic membrane with a wide range...

Polypropylene (PP) syringe filters are designed for aqueous or organic solutions that have high levels of debris and for difficult-to-filter solutions. It's a hydrophilic membrane with a wide range...

Polypropylene (PP) syringe filters are designed for aqueous or organic solutions that have high levels of debris and for difficult-to-filter solutions. It's a hydrophilic membrane with a wide range...

Polypropylene (PP) syringe filters are designed for aqueous or organic solutions that have high levels of debris and for difficult-to-filter solutions. It's a hydrophilic membrane with a wide range...

Polypropylene (PP) syringe filters are designed for aqueous or organic solutions that have high levels of debris and for difficult-to-filter solutions. It's a hydrophilic membrane with a wide range...

Polypropylene (PP) syringe filters are designed for aqueous or organic solutions that have high levels of debris and for difficult-to-filter solutions. It's a hydrophilic membrane with a wide range...

’s Polypropylene Vials are molded from high-purity, noncytotoxic, nonpyrogenic, low-metal content polypropylene copolymer. The vials are pressure-tested together at 7.5 psig for safe air shipment and...

Pomalidomide is a derivative of Thalidomide (Cat. No. 2020) and a second-generation immunomodulatory drug. Pomalidomide targets the E3 ligase protein cereblon, preventing cereblon autoubiquitination...

A member of the ecdysteroid family. Ecdysone receptor (EcR) agonist. An analog of ecdysone with similar properties to muristerone A. Induces expression of β-galactosidase to levels similar to those...

Ponatinib is a multi-targeted tyrosine kinase inhibitor that is active against T315I and other BCR-Abl mutants. It inhibits all tested BCR-Abl mutants in cellular and biochemical assays, suppresses...

Ponesimod is a potent agonist of sphingosine-1-phosphate receptor 1 (S1P1) receptor. It reduces the circulating lymphocytes at a dose of 3-100 mg/kg in a rat model. It selectively activates S1P1 in a...

Posaconazole is a broad-spectrum, second-generation triazole compound that displays antifungal activity. Posaconazole inhibits the growth of fungi by inhibiting the lanosterol 14α-demethylase enzyme...

Provided as a stock solution for making various biological buffers and salt solutions2115 | Potassium Chloride Solution (KCl) DataSheetSort Name: Potassium Chloride Solution (KCl)Label Name:...

K940 | Potassium Serum Detection Assay Kit Fluorometric DataSheet

Poziotinib is an irreversible Pan-HER inhibitor with IC₅₀s of 3 nM, 5 nM and 23 nM for HER1, HER2, and HER4 respectively. Displays antineoplastic activity.Poziotinib is an irreversible Pan-HER...

Cell-permeable. A potent Src-selective tyrosine kinase (TK) inhibitor. Inhibits p56lck and p59fynT (IC₅₀ values are 5 and 6 nM respectively). Displays > 8000-fold selectivity over ZAP-70 and JAK2...

PP121 is a dual inhibitor of tyrosine and phosphoinositide kinases. PP121 inhibits both tyrosine kinases and PI3-Ks but not serine-threonine kinases. It potently inhibits p110α, p110β, p110γ, p110δ,...

An inhibitor of the Src family of kinases. Inhibits Src and Lck kinase with IC₅₀ values of 36 nM and 31 nM respectively. Also shown to inhibit RIP2( IC₅₀ = 19 nM) and CK1δ (IC₅₀ = 41 nM).PP2 is an...

A potent and selective in vitro mTOR inhibitor that targets the ATP domain of mTOR (IC₅₀ = 8 nM). Inhibits other PI 3-Kinases only at much higher concentrations. Recently it has been shown that PP242...

A negative control for the Src family kinase inhibitor PP2 (Cat. No. 1767-1,5). Inhibits the activity of EGFR kinase at an IC₅₀ = 2.7 μM.PP3 is a negative control for the Src family kinase inhibitor...

PPA1 (Pyrophosphatase) belongs to the PPase family. This protein is an enzyme that catalyzes the conversion of one molecule of pyrophosphate to two phosphate ions. The hydrolysis of inorganic...

A highly potent, selective and irreversible thrombin inhibitor.PPACK Dihydrochloride is a highly potent, selective and irreversible thrombin inhibitor.1848 | PPACK Dihydrochloride DataSheetAlternate...

PPACKII is a specific and irreversible inhibitor of glandular and plasma kallikreins. Human tissue kallikreins (hKs) are a class of secreted serine proteases that involved in the release of...

The peroxisome proliferator activated receptor (PPAR) family of ligand-activated transcription factors consists of three subtypes encoded by separate genes: PPAR, PPAR and PPAR. Of these, PPAR plays...

3809BP | PPAR gamma Blocking Peptide DataSheetAntibody Target: PPAR gamma Accession #: P37231Gene ID: 5468Appearance: Colorless liquidConcentration: 0.5 mg/mlFormulation: 50 µg (0.5 mg/ml) in...

3585 | Anti-PPAR? Polyclonal Antibody DataSheet

3585BP | PPAR-alpha Blocking Peptide DataSheetAntibody Target: PPAR-alpha Accession #: Q07869Gene ID: 5465Appearance: Colorless liquidConcentration: 0.5 mg/mlFormulation: 50 µg (0.5 mg/ml) in...

6833 | PPARG polyclonal antibody DataSheet

Peroxisome proliferators are non-genotoxic carcinogens which are purported to exert their effect on cells through their interaction with members of the nuclear hormone receptor family termed...

K437 | PPARα Ligand Screening/Characterization Assay Kit Fluorometric DataSheet

Cell-permeable. A dipeptide that acts as a selective and reversible PPARγ antagonist (KD ~ 8 µM). Shown to inhibit the agonist activity of Rosiglitazone (100 nM) in a dose-dependent manner (IC₅₀= 31...

K456 | PPDK Pyruvate, phosphate dikinase Activity Assay Kit Fluorometric/Colorimetric DataSheet

PPM1F is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase can interact with Rho...

PPP1CC, also known as serine/threonine-protein phosphatase PP1-gamma catalytic subunit, is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility...

PPQ-102 | B3353Description: PPQ -102 is a potent, voltage-independent CFTR chloride channel inhibitor (IC50 = 90 nM). PPQ-102 displays nephroprotective and anti-fibrotic activities, decreasing the...

PQR-309 is a potent pan inhibitor of phosphoinositide-3-kinases (PI3K) and inhibitor of the mammalian target of rapamycin (mTOR), with potential antineoplastic activity. PQR-309 inhibits the PI3K...

Prasugrel is novel thienopyridine antiplatelet prodrug that is metabolized to the thiol-containing active metabolite R-138727,which binds to and irreversibly inhibits the platelet P2Y12ADP receptor...

Pravastatin is a HMG-CoA (Hydroxymethylglutaryl-coenzyme A reductase) inhibitor that is a ring hydroxylated metabolite of mevastatin (Cat. No. 1694). It is a competitive inhibitor of HMG-CoA...

Prazosin is an antagonist of α1-adrenergic receptors (α1-ARs). The affinity estimates (pKi) for inhibition of [3H]-prazosin binding to CHO-K1 cells expressing cloned human α1A, α1B and α1D...

PRE-084 is a high affinity sigma receptor 1 (σ1) agonist. It shows Ki values of 2.2 and 13,091 nM for σ1 and σ2 receptors, respectively and an IC₅₀ of 44 nM in the sigma receptor assay. It does not...

offers low price and high quality Pre-designed siRNA Oligo Set for the customers who intend to ensure the inhibition efficiency in siRNA experiments. The customer needs to provide us the Gene Name...

offers low price and high quality Pre-designed siRNA Oligo Set for the customers who intend to ensure the inhibition efficiency in siRNA experiments. The customer needs to provide us the Gene Name...

K583 | Preadipocyte Isolation Kit DataSheet

E4633 | Pregnenolone Elisa Kit DataSheet

Prekallikrein is the glycosylated single chain zymogen precursor of the plasma serine protease kallikrein. Plasma prekallikrein circulates with kininogen and is activated by Factor XIIa in the...

3482 | Presenilin 2 Antibody DataSheet

E4696 | Presepsin Human Elisa Kit DataSheet

Pretomanid is a nitroimidazopyran active againt Mycobacterium tuberculosis. It is active against multidrug-resistant M. tuberculosis clinical isolates with MIC

Prexasertib is a potent inhibitor of checkpoint kinase 1 (chk1) with potential antineoplastic activity. Upon administration, prexasertib selectively binds to chk1, thereby preventing activity of chk1...

PRI-724 (C-82 prodrug, ICG-001 analog) is a potent and specific inhibitor of the canonical Wnt signaling pathway. PRI-724 specifically inhibits the recruiting of beta-catenin with its coactivator CBP...

Pridopidine is a phenylpiperidine dopaminergic stabilizer. It is a low affinity dopamine D2 receptor antagonist and a potent sigma-1 receptor (S1R) agonist. The affinity of pridopidine for S1R is...

A small molecule that restores tumor suppressor function to mutant p53 proteins. PRIMA-1 acts as an inducer of apoptosis and inhibitor of growth of human tumors with mutant p53. PRIMA-1 restores...

PRIMA-1MET is a methylated derivative of PRIMA-1 (Cat. No. 2170). Restores mutant activity p53 activity. Acts synergistically with chemotherapeutic agents to inhibit tumor cell proliferation. At...

Prionex®, a very effective BSA alternate, is a 10% aqueous solution of a polypeptide fraction of highly purified dermal collagen of porcine origin. It has excellent protein stabilizing properties...

Pristimerin is a potent and reversible inhibitor of monoacylglycerol lipase (MGL) (IC50 = 93 nM). Pristimerin inhibits inflammation and tumor angiogenesis and significantly reduces vessel density in...

Pritelivir is a potent helicase primase inhibitor. It inhibits replication of herpes simplex virus (HSV) type 1 and type 2 in the nanomolar range in vitro by abrogating the enzymatic activity of the...

P0108 is a potent inhibitor of phosphatase of regenerating liver-3 (PRL-3) (IC₅₀ = 0.9 μM). It reduces the invasive properties of mouse melanoma B16F10 cells in a cellular model. Sensitizes...

3935 | PRMT-5 Antibody DataSheet

3935BP | PRMT-5 Blocking Peptide DataSheetAntibody Target: PRMT-5Accession #: EDM14175.1Gene ID: 364382Appearance: Colorless liquidConcentration: 0.5 mg/mlFormulation: 50 µg (0.5 mg/ml) in phosphate...

3792 | PRMT1 Antibody DataSheet

PRMT1 methylate’s (mono & asymmetric dimethylation) the guanidino nitrogens of arginyl residues present in a glycine and arginine-rich domain (may methylate HNRNPA1 and histones) methylate’s SUPT5H...

PRMT1 methylate’s (mono & asymmetric dimethylation) the guanidino nitrogens of arginyl residues present in a glycine and arginine-rich domain (may methylate HNRNPA1 and histones) methylate’s SUPT5H...

PRMT4/CARM1 Inhibitor is highly selective in blocking the activity of Protein Arginine Methyltransferase 4/Coactivator-Associated Arginine Methyltransferase 1. The IC₅₀ value of inhibition is 7.1 µM...

3086BP | PRMT6 Blocking Peptide DataSheetAntibody Target: PRMT6Accession #: Q96LA8 Gene ID: 55170Appearance: Colorless liquidConcentration: 0.5 mg/mlFormulation: 50 µg (0.5 mg/ml) in phosphate...

3059 | PRMT7 Antibody DataSheet

3059BP | PRMT7 blocking peptide DataSheetAntibody Target: PRMT7Accession #: Q9NVM4Gene ID: 54496Appearance: Colorless liquidConcentration: 0.5 mg/mlFormulation: 50 µg (0.5 mg/ml) in phosphate...

MMP-13 (Collagenase-3) was first identified in human mammacarcinoma (Freije et al., 1994, Willmroth et al. 1998) - probably induced by IL1- alpha and IL-1 beta - and shown to be glycosylated and the...

The proGelatinase A, a member of the matrix metalloproteinase (MMP) family, has been isolated from macrophages and fibroblasts. Gelatinase A hydrolyses several components of the extracellular matrix,...

Human neutrophil collagenase (HNC) has been purified from extracts of fresh and outdated buffy coats and from exudates of phorbol myristate acetate-stimulated neutrophils. The MMP-8 present in the...