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RU-521 (RU-320521) is a potent, selective cyclic GMP-AMP synthase (cGAS) inhibitor (Kd = 36.2 nM). RU-521 is active and selective in cellular assays of cyclic GMP-AMP synthase-mediated signaling and...

A specific androgen receptor antagonist; displays dramatic effect on hair regrowth.RU-58841 is a specific androgen receptor antagonist; displays dramatic effect on hair regrowth.B2325 | RU-58841...

E4666 | Rubella IgG Elisa Kit DataSheet

E4667 | Rubella IgM Elisa Kit DataSheet

Rubratoxin A is a mycotoxin and protein phosphatase 2A (PP2A) inhibitor. Does not inhibit PP1, PP2B, PTP1B, ALP and CIP. It causes suppression of tumor metastasis and reduction of primary tumor...

Rubusoside (Rub) is a natural sweetener from the Chinese sweet tea plant (Rubus suavissimus). Rubusoside inhibits transport by both GLUT1 and GLUT5.Rubusoside (Rub) is a natural sweetener from the...

6829 | Runx1/AML1-ETO polyclonal antibody DataSheet

6773 | Runx2 Antibody DataSheet

Ruthenium red is an inhibitor of mitochondrial Ca²⁺ uniporter; also blocks cell membrane-located capsaicin-activated cation channels (IC₅₀ = 14 nM) and voltage-sensitive Ca²⁺ channels to inhibit...

Ruxolitinib phosphate is the phosphate salt form of ruxolitinib, a potent Janus-associated kinase (JAK) inhibitor with potential antineoplastic and immunomodulating activities. Ruxolitinib...

Ruxolitinib is a potent and selective Janus kinase (JAK) inhibitor with with IC₅₀'s of 2.7 and 4.5 nM for JAK1 and JAK2, respectively. Displays clinically significant activity in myelofibrosis...

RVX-208 is a potent inhibitor of BET bromodomains. It increases apolipoprotein A-I and high-density lipoprotein cholesterol in vitro and in vivo.RVX-208 is a potent inhibitor of BET bromodomains. It...

RWJ-67657 is a potent inhibitor of the MAP kinases p38α and p38β (IC₅₀s = 1 and 11 µM, respectively, in vitro); inactive against p38γ and p38δ, as well as several other kinases. RWJ-67657 blocks the...

Ryanodine is a naturally occurring poisonous alkaloid that acts as a potent inhibitor of Ca²⁺ release from sarcoplasmic reticulum (IC₅₀s = 10 and 2.8 nM in skeletal and cardiac muscle, respectively)...

Ryuvidine is a potent inhibitor of SET domain-containing protein 8 (SETD8) (IC₅₀ = 0.5 µM) that suppresses monomethylation of H4K20 in vitro. It displays weak inhibiton against cyclin-dependent...

IGF-I (insulin-like Growth Factor-I) is a polypeptide growth factor that stimulates the proliferation of a wide range of cell types including muscle, bone, and cartilage tissue. ’s recombinant human...

6945 | S- Adenosylhomocysteine Antibody (Clone # 301-10) DataSheet

6942 | S- Adenosylmethionine Antibody (Clone # 118-18) DataSheet

6940 | S- Adenosylmethionine Antibody (Clone # 118-6) DataSheet

6943 | S- Adenosylmethionine Antibody (Clone # 84-19) DataSheet

6941 | S- Adenosylmethionine Antibody (Clone # 84-3) DataSheet

6944 | Anti-S-Adenosylmethionine Antibody DataSheet

SAM is a ubiquitous methyl donor. It is a cofactor for methyl transferases such as catechol O-methyltransferase (COMT) and DNA methyltransferase. Most of it is present in the liver, where 85% of all...

3958 | S-100 Antibody DataSheet

3958BP | S-100 Blocking Peptide DataSheetAntibody Target: S-100Accession #: P23297Gene ID: 6271Appearance: Colorless liquidConcentration: 0.5 mg/mlFormulation: 50 µg (0.5 mg/ml) in phosphate buffered...

Biological Significance: S-100 is a low molecular weight, cytoplasmic, calcium binding protein. It is traditionally found in the brain, heart and muscle tissue. S-100 has two subunits (alpha-chain...

A methyl donor and a cofactor for enzyme-catalyzed methylations, including catechol O-methyltransferase (COMT) and DNA methyltransferases (DNMT). Although present in all cells, it is concentrated in...

S-Adenosylhomocysteine SAH Elisa Kit | E4542

E4541 | S-Adenosylmethionine SAM Elisa Kit DataSheet

S-Adenosylmethionine synthase, (AdoMetS), (E.C. 2.5.1.6) catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential...

3990 | S-Tag Antibody DataSheet

3990BP | S-Tag Blocking Peptide DataSheetAntibody Target: S-tagAccession #: N/AGene ID: N/AAppearance: Colorless liquidConcentration: 0.5 mg/mlFormulation: 50 µg (0.5 mg/ml) in phosphate buffered...

S0859 is a selective high-affinity generic inhibitor of the Na⁺/HCO3- sodium bicarbonate co-transporter (NBC). S0859 does not inhibit Na⁺-H⁺ exchange (NHE). S0859 could be potentially important for...

6196 | S100A8 Antibody (Clone I mg48M7C7) DataSheet

S100B also known as protein S100-B. S100B is a protein of the S100 protein family. S100 proteins comprise a multigene family of EF-hand calcium binding proteins that engage in multiple functions in...

S107 free base | B3354Description: S107 is a Type 1 ryanodine receptor (RyR1) stabilizer that binds RyR1 and enhances the binding affinity of calstabin-1. The intracellular Ca2+ leak was...

S1RA is a highly selective sigma-1 (σ1) receptor antagonist. It shows high affinity for σ1 receptors with Ki values of 17 nM and 23.5 nM for human and guinea pig σ1 receptors respectively but no...

S63845 is a potent and selective small molecule MCL1 inhibitor with Ki < 1.2 nM. S63845 potently kills MCL1-dependent cancer cells, including multiple myeloma, leukaemia and lymphoma cells, by...

SA4503 is a potent sigma-1 (σ1 receptor) agonist. It shows 100 fold higher affinity for σ1 than σ2 receptor with IC₅₀ values of 17.4 nM and 1784 nM against 200 nM (+)-pentazocine for binding σ...

SAA1 protein is an acute phase apolipoprotein reactant which is produced mostly by hepatocytes and under regulation of inflammatory cytokines. SAA1 (Serum amyloid A1) protein is produced mainly in...

Safe Image Super™ DNA StainM1198 | Safe Image Super™ DNA Stain DataSheetSort Name: Safe Image Super™ DNA StainLabel Name: Safe Image Super™ DNA StainTaglines: Safe Image Super™ DNA StainProduct...

Safe Image™ Basic DNA StainM1193 | Safe Image™ Basic DNA Stain DataSheetSort Name: Safe Image™ Basic DNA StainLabel Name: Safe Image™ Basic DNA StainTaglines: Safe Image™ Basic DNA StainProduct...

Safe Image™ DNA Stain PackM1197 | Safe Image™ DNA Stain Pack DataSheetSort Name: Safe Image™ DNA Stain PackLabel Name: Safe Image™ DNA Stain PackTaglines: Safe Image™ DNA Stain PackProduct...

Safe Image™ Fire Red DNA StainM1199 | Safe Image™ Fire Red DNA Stain DataSheetSort Name: Safe Image™ Fire Red DNA StainLabel Name: Safe Image™ Fire Red DNA StainTaglines: Safe Image™ Fire Red DNA...

Safe Image™ Green DNA StainM1194 | Safe Image™ Green DNA Stain DataSheetSort Name: Safe Image™ Green DNA StainLabel Name: Safe Image™ Green DNA StainTaglines: Safe Image™ Green DNA StainProduct...

Safe Image™ Red DNA StainM1195 | Safe Image™ Red DNA Stain DataSheetSort Name: Safe Image™ Red DNA StainLabel Name: Safe Image™ Red DNA StainTaglines: Safe Image™ Red DNA StainProduct Highlights:...

Safe ImageTMWhite DNA StainM1196 | Safe Image™ White DNA Stain DataSheetSort Name: Safe Image™ White DNA StainLabel Name: Safe Image™ White DNA StainTaglines: Safe Image™ White DNA StainProduct...

Safinamide is a highly selective and reversible monoamine oxidase type B (MAO-B) inhibitor that increases neostriatal dopamine concentration. In addition, Safinamide also acts as a voltage-dependent...

A cell-permeable, highly active, Sonic hedgehog (Shh) signaling agonist. Smoothened (Smo) agonist.SAG Agonist is a cell-permeable, highly active, Sonic hedgehog (Shh) signaling agonist. Smoothened...

A cell-permeable, low toxicity, Sonic hedgehog (Shh) signaling agonist. Smoothened (Smo) agonist. Also acts as a potent activator of VEGF expression in vitro.SAG Agonist is a cell-permeable, low...

Potent, reversible inhibitor of histone deacetylase 1 (HDAC1) and 3 (HDAC3). Induces cell growth arrest at both G1 and G2 phases. Induces apoptosis.SAHA is a potent, reversible inhibitor of histone...

SAHA-BPyne is a SAHA derivative with a benzophenone crosslinker and an alkyne tag. It is a photoreactive “clickable“ probe. It is used to profile histone deacetylase (HDAC) activities in native...

6684 | SAHH/AHCY Antibody DataSheet

K4209 | Salbutamol SALB Elisa Kit DataSheet

Cell-permeable. Salermide is an inhibitor of SIRT1 and SIRT2. In vitro, Salermide has a stronger inhibitory effect on SIRT2 than on SIRT1. It induces massive apoptosis in tumor cells through...

K494 | Salicylate Assay Kit Colorimetric DataSheet

Salinomycin is a polyether ionophore antibiotic that has recently been identified as an antitumor drug for several types of cancer stem cell (CSC) treatments. Salinomycin inhibits the migration and...

Salirasib is a potent Inhibitor of active Ras proteins. It displaces active Ras from the plasma membrane; impairs downstream signaling and inhibits proliferation of endometrial carcinoma cells. Also...

3237 | SALL1 Antibody DataSheet

3237BP | SALL1 Blocking Peptide DataSheetAntibody Target: SALL1Accession #: D3ZIF4 Gene ID: 307740Appearance: Colorless liquidConcentration: 0.5 mg/mlFormulation: 50 µg (0.5 mg/ml) in phosphate...

E4678 | Salmonella Typhi IgG Elisa Kit DataSheet

E4679 | Salmonella Typhi IgM Elisa Kit DataSheet

Cell-permeable. A selective inhibitor of cellular phosphatase complexes that dephosphorylate eukaryotic translation initiation factor 2 subunit α (eIF-2α). Also protects cells from endoplasmic...

Salvianolic acid B is an antioxidant and anti-inflammatory compound extracted from Salvia miltiorrhiza. It shows cardioprotective and chemopreventative properties. It shows high free radical...

Salvinorn B is a potent and selective κ-opioid DREADD (KORD) agonist (EC₅₀ = 11.8 nM). DREADDs are chemogenetic tools widely used to remotely control cellular signaling, neuronal activity, and...

Sanguinarine is a benzylisoquinoline alkaloid that inhibits PP2C and shows selectivity for PP2C over PP1, PP2A, and PP2B in vitro. It inhibits MKP-1 with an IC₅₀ of 10 μM and shows selectivity for...

Cell-permeable. A potent inhibitor of Sonic hedgehog (Shh) signaling; high affinity antagonist of smoothened activity (Kd = 1.2 nM). Inhibits smoothened agonist effects with an IC₅₀of 20 nM in...

Cell-permeable. A potent antagonist of Hedgehog (Hh) signaling pathway. Antagonizes smoothened receptor activity (KD = 12 nM) and inhibits SAG (Cat. No. 1939-500,1000) activity. SANT-2 should be a...

Sapacitabine is an orally bioavailable nucleoside analog prodrug that is potentially useful for treatment of hematologic malignancies and solid tumors. The active metabolite of sapacitabine, CNDAC...

Saquinavir mesylate is a HIV protease inhibitor (Kis = 0.12 and < 0.1 nM for HIV-1 and HIV-2 protease, respectively) that displays antiviral activity with low cytotoxicity.Saquinavir mesylate is a...

SAR-125844 is a potent, selective, reversible and ATP-competitive c-MET inhibitor, with an IC₅₀ of 4.2 nM. Displays inhibition of MET autophosphorylation in cell-based assays. Upon intravenous...

SAR-131675 is a potent and specific VEGFR-3 inhibitor. It inhibits VEGFR-3 tyrosine kinase activity (IC₅₀ = 20 nmol/L) and VEGFR-3 autophosphorylation (IC₅₀ = 5 nmol/L) in HEK cells, respectively...

SAR-20347 is a novel specific dual inhibitor of JAK1 and tyrosine kinase 2 (TYK2), inhibiting JAK1- and/or TYK2-dependent signaling from the IL-12/IL-23, IL-22, and IFN-alpha receptors.SAR-20347 is a...

SAR260301 is a potent and selective Class I phosphatidylinositol-3-kinase-β (PI3K-β) specific inhibitor with an IC₅₀ of 52 nM for this isoform. SAR260301 displays improved physicochemical and in...

SAR-405 is a potent and selective PIK3C3/Vps34 inhibitor that prevents autophagy and synergizes with mTOR inhibition in tumor cells.SAR-405 is a potent and selective PIK3C3/Vps34 inhibitor that...

SAR-407899  free base | B3356Description: SAR-407899 is a potent and selective Rho kinase (ROCK) inhibitor with potential antihypertensive activity. SAR-407899 is equipotent against human and...

AZD0530 is a dually active inhibitor of c-Src and Bcr-ABL, on bone resorption. AZD0530 inhibited tumor growth in a manner independent of dose and inhibited phosphorylation of focal adhesion kinase...

K636 | Sarcosine Colorimetric/Fluorometric Assay Kit DataSheet

Sarcosine is an intermediate in the metabolism of glycine. Sarcosine is an antagonist of glycine transporter-1 (GlyT1) with an IC₅₀ value of 91 μM. It has beneficial effects in schizophrenia...

Sardomozide Hydrochloride is a second-generation polyamine synthesis inhibitor, that inhibits the activity of the polyamine biosynthetic enzyme S-adenosylmethionine decarboxylase (SAMDC). Sardomozide...

Sarecycline is a semi-synthetic tetracycline, narrow-spectrum antibiotic being developed for use as an oral once daily antibiotic treatment for patients suffering from moderate to severe acne...

Sarecycline is a semi-synthetic tetracycline, narrow-spectrum antibiotic, being developed to treat patients suffering from moderate to severe acne vulgaris. Sarecycline is more active than...

SARS-CoV is an enveloped, single and positive-stranded RNA virus. Cell entry of severe acute respiratory syndrome coronavirus (SARS-CoV) is mediated by the viral spike (S) protein. The spike (S)...

A protein modification reagent used to convert primary amine groups into protected sulfhydryls (-SH). The sulfhydryl is readily made available for use in subsequent reactions by treatment with...

Isolated from Saururus chinensis. Displays cytoprotective and antioxidant activities in cultured hepatocytes. Suppresses NF-kB p65 activity. Neuroprotective. Bone resorption/osteoclastogenesis...

Savolitinib is an inhibitor of cMET tyrosine kinase or hepatocyte growth factor receptor (HGFR). It potently inhibits the tyrosine kinase activity of recombinant cMET in vitro with an IC₅₀ value of 4...

Saxagliptin is hydroxyadamantyl compound that acts as a potent, selective and reversible dipeptidyl peptidase-4 (DPP-4) inhibitor (IC₅₀ = 26 nM). An anti-diabetic agent.Saxagliptin is...

SB 202190 is a highly selective, potent, cell-permeable inhibitor of p38 MAP kinases, inhibiting p38α (SAPK2A, MAPK14) and p38β (SAPK2B, MAPK11) with IC₅₀ values of 50 and 100 nM, respectively. At...

Cell-permeable. Selective inhibitor of p38 mitogen-activated protein kinase (MAP Kinase) (IC₅₀ values are 50 and 500 nM for SAPK2a/p38 and SAPK2b/p38β2 respectively). Displays 100-500-fold...

A potent, cell-permeable and ATP-competitive inhibitor of glycogen synthase kinase-3 (GSK-3) (Ki= 9 nM for GSK-3α). Has little activity against 24 other protein kinases (IC₅₀ > 10 μM). Stimulates...

An orally available pan-histone deacetylase (HDAC) inhibitor binding all HDAC isozymes with similar affinity (Kis = 16-28 nM) with the exception of HDAC6 and 7 (Kis = 247 and 104 nM, respectively)...

SB-204490 is a potent and specific ATP citrate lyase (ACLY) inhibitor. Prodrug of SB-201076. Inhibits cholesterol and fatty acid synthesis in a dose-dependent manner in HepG2 cells.SB-204490 is a...

SB-225002 is a potent and selective inhibitor of chemokine receptor CXCR2 with an IC50 of 22 nM for inhibiting interleukin IL-8 binding to CXCR2; displays > 150-fold selectivity over CXCR1 receptors...

SB-242235 is a potent and selective p38 MAP kinase inhibitor (IC₅₀ = 1.0 uM).SB-242235 is a potent and selective p38 MAP kinase inhibitor (IC₅₀ = 1.0 uM).B2273 | SB-242235 DataSheetAlternate...

SB-265610 is a potent and selective CXCR2 chemokine receptor antagonist (Kd = 2.5 nM). It does not bind to CXCR1). Inhibits CINC-induced chemotaxis and attenuates neutrophil accumulation in...

SB-297006 is a C-C chemokine receptor-3 antagonist (CCR3; IC₅₀ = 39 nM).SB-297006 is a C-C chemokine receptor-3 antagonist (CCR3; IC₅₀ = 39 nM).B2589 | SB-297006 DataSheetAlternate Name/Synonyms:...

SB-415286 is a potent, selective and ATP-competitive glycogen synthase kinase-3 (GSK-3) inhibitor (Ki = 31 nM for GSK-3α). Displays minimal activity against 24 other protein kinases (IC₅₀ > 10 μ M)...

A potent and selective inhibitor of the TGF-β1 receptor ALK5 (IC₅₀ = 94 nM). It inhibits ALK4 only at higher concentrations (IC₅₀ = 140 nM). Suppresses renewal in embryonic and induced pluripotent...

SB-525334 is a potent and selective inhibitor of transforming growth factor-β receptor I (ALK5, TGF-βRI) (IC₅₀ = 14.3 nM); displays 4-fold less potency against ALK4 (IC₅₀ = 58.5 nM) and inactive as...

SB590885 is a potent B-Raf inhibitor with Ki of 0.16 nM, 11-fold greater selectivity for B-Raf over c-Raf, no inhibition to other human kinases.SB590885 is a potent B-Raf inhibitor with Ki of 0.16...