3-Acetyl-11-keto β boswellic acid | B2783

3-Acetyl-11-keto β boswellic acid (AKBA) is a naturally occurring pentacyclic triterpene that acts as an antiangiogenic and neuroprotective agent, reducing the impact of proliferative retinopathies, protecting neurons against ischemic injury involving the Nrf2/HO-1 pathway. It selectively inhibits 5-lipoxygenase (IC50 = 1.5 µM) in an enzyme-directed, nonredox, and noncompetitive manner. AKBA and its analogues may be useful in place of non-steroidal anti-inflammatory drugs (NSAID) to control inflammatory responses with milder side effects.

3-Acetyl-11-keto β boswellic acid (AKBA) is a naturally occurring pentacyclic triterpene that acts as an antiangiogenic and neuroprotective agent, reducing the impact of proliferative retinopathies, protecting neurons against ischemic injury involving the Nrf2/HO-1 pathway. It selectively inhibits 5-lipoxygenase (IC50 = 1.5 µM) in an enzyme-directed, nonredox, and noncompetitive manner. AKBA and its analogues may be useful in place of non-steroidal anti-inflammatory drugs (NSAID) to control inflammatory responses with milder side effects.

B2783 | 3-Acetyl-11-keto β boswellic acid DataSheet

Alternate Name/Synonyms: Acetylketo-β-boswellic acid,AKBA,3-O-acetyl-11-keto-β-Boswellic acid

Appearance: White to off-white solid

Formulation:

CAS Number: 67416-61-9

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₃₂H₄₈O₅

Molecular Weight: 512.72

Cell-Permeable?: TRUE

Purity: ≥98%

Solubilities: ~5 mg/ml DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: An antiangiogenic and neuroprotective agent

MDL Number: MFCD03788777

PubChem CID: 11168203

SMILES: CC1CCC2(CCC3(C(=CC(=O)C4C3(CCC5C4(CCC(C5(C)C(=O)O)OC(=O)C)C)C)C2C1C)C)C

InChi: InChI=1S/C32H48O5/c1-18-9-12-28(4)15-16-30(6)21(25(28)19(18)2)17-22(34)26-29(5)13-11-24(37-20(3)33)32(8,27(35)36)23(29)10-14-31(26,30)7/h17-19,23-26H,9-16H2,1-8H3,(H,35,36)/t18-,19+,23-,24-,25+,26-,28-,29+,30-,31-,32-/m1/s1

InChi Key: HMMGKOVEOFBCAU-BCDBGHSCSA-N