4-Iodo-SAHA | B2800

4-iodo-SAHA is a hydrophobic derivative of the class I and class II HDAC (histone deacetylase) inhibitor SAHA. At 1 μM it demonstrates >60% inhibition of HDAC1 and HDAC6 activity in a deacetylase activity assay, similar to that of SAHA. 4-iodo-SAHA inhibits proliferation of SK-BR-3 breast-derived cell lines, HT29 colon-derived cell lines, leukemia-derived U937 tumor cell line, JA16, HL60 and K562 cell lines with EC50 values of 1.1 μM, 0.95 μM, 0.12 μM, 0.24 μM, 0.85 μM and 1.3 μM, respectively. It is 10-fold more potent as an inhibitor of U937 leukemia cell proliferation compared to SAHA.

4-iodo-SAHA is a hydrophobic derivative of the class I and class II HDAC (histone deacetylase) inhibitor SAHA. At 1 μM it demonstrates >60% inhibition of HDAC1 and HDAC6 activity in a deacetylase activity assay, similar to that of SAHA. 4-iodo-SAHA inhibits proliferation of SK-BR-3 breast-derived cell lines, HT29 colon-derived cell lines, leukemia-derived U937 tumor cell line, JA16, HL60 and K562 cell lines with EC50 values of 1.1 μM, 0.95 μM, 0.12 μM, 0.24 μM, 0.85 μM and 1.3 μM, respectively. It is 10-fold more potent as an inhibitor of U937 leukemia cell proliferation compared to SAHA.

B2800 | 4-Iodo-SAHA DataSheet

Alternate Name/Synonyms: 4-iodo-SAHA, 4-Iodo Suberoylanilide Hydroxamic Acid, N1-hydroxy-N8-(4-iodophenyl)octanediamide, N~1~-Hydroxy-N~8~-(4-iodophenyl)octanediamide

Appearance: Crystalline solid

Formulation:

CAS Number: 1219807-87-0

Structure Available?: True

Peptide sequence:

Salt Form: False

Molecular Formula: C₁₄H₁₉IN₂O₃

Molecular Weight: 390.22

Cell-Permeable?: True

Purity: ≥98%

Solubilities: ~ 30 mg/ml in DMSO and DMF in 0, ~ 0.2 mg/ml in in Ethanol

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A hydrophobic derivative of HDAC inhibitor SAHA

MDL Number:

PubChem CID: 46205754

SMILES: C1=CC(=CC=C1NC(=O)CCCCCCC(=O)NO)I

InChi: 1S/C14H19IN2O3/c15-11-7-9-12(10-8-11)16-13(18)5-3-1-2-4-6-14(19)17-20/h7-10,20H,1-6H2,(H,16,18)(H,17,19)

InChi Key: BYVHZKAHBXINPL-UHFFFAOYSA-N