5’-Deoxy-5’-methylthioadenosine | B1053

5'-Deoxy-5'-methylthioadenosine (MTA) is an intermediate in the generation of adenine and methionine that is produced by the decarboxylation of S-adenosylmethionine. Acts as a potent agonist of adenosine receptors (Kis = 0.15, 1.13, 13.9, and 0.68 μM for A1, A2A, A2B, and A3, respectively). At higher concentrations, MTA inhibits several enzymes, including protein carboxylmethyltransferase (Ki = 41 μM), S-adenosylhomocysteine hydrolase, SET methyltransferases, and spermidine and spermine synthases.

5'-Deoxy-5'-methylthioadenosine (MTA) is an intermediate in the generation of adenine and methionine that is produced by the decarboxylation of S-adenosylmethionine. Acts as a potent agonist of adenosine receptors (Kis = 0.15, 1.13, 13.9, and 0.68 μM for A1, A2A, A2B, and A3, respectively). At higher concentrations, MTA inhibits several enzymes, including protein carboxylmethyltransferase (Ki = 41 μM), S-adenosylhomocysteine hydrolase, SET methyltransferases, and spermidine and spermine synthases.

B1053 | 5’-Deoxy-5’-methylthioadenosine DataSheet

Alternate Name/Synonyms: 5'-S-methyl-5'-thio-adenosine; Methylthioadenosine; MTA; NSC 335422; Vitamil L2

Appearance: White to off-white solid

Formulation: N/A

CAS Number: 2457-80-9

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₁H₁₅N₅O₃S

Molecular Weight: 297.3

Cell-Permeable?: Yes

Purity: ≥98%

Solubilities: DMSO (~25 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A methyltransferase inhibitor

MDL Number: MFCD00010533

PubChem CID: 439176

SMILES: CSCC1C(C(C(O1)N2C=NC3=C2N=CN=C3N)O)O

InChi: InChI=1S/C11H15N5O3S/c1-20-2-5-7(17)8(18)11(19-5)16-4-15-6-9(12)13-3-14-10(6)16/h3-5,7-8,11,17-18H,2H2,1H3,(H2,12,13,14)/t5-,7-,8-,11-/m1/s1

InChi Key: WUUGFSXJNOTRMR-IOSLPCCCSA-N