6-Aminonicotinamide | B1047

6-aminonicotinamide (6-AN) is inhibitor of glucose-6-phosphate dehydrogenase (G6PD), which catalyzes the conversion of G-6-P to 6-phosphogluconolactone, the first step of the pentose phosphate pathway. 6-AN has been widely used as a chemical tool in various experimental systems to study the biological consequences of inhibiting pentose phosphate pathway. Due to the essential roles of this pathway in generating reducing power (NADPH) and important metabolic intermediates (pentose-5-phosphate) for synthesis of macromolecules, it is not surprising that 6-AN exhibits anticancer activity in vitro, causes oxidative stress, and sensitizes cells to anticancer agents and radiation.

6-aminonicotinamide (6-AN) is inhibitor of glucose-6-phosphate dehydrogenase (G6PD), which catalyzes the conversion of G-6-P to 6-phosphogluconolactone, the first step of the pentose phosphate pathway.

B1047 | 6-Aminonicotinamide DataSheet

Alternate Name/Synonyms: 6-amino-3-pyridinecarboxamide; 6-AN; NSC21206; SR4388

Appearance: White to off-white solid

Formulation: N/A

CAS Number: 329-89-5

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₆H₇N₃O

Molecular Weight: 137.1

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (~ 1 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: An inhibitor of glucose-6-phosphate dehydrogenase (G6PD)

MDL Number: MFCD00006327

PubChem CID: 9500

SMILES: C1=CC(=NC=C1C(=O)N)N

InChi: InChI=1S/C6H7N3O/c7-5-2-1-4(3-9-5)6(8)10/h1-3H,(H2,7,9)(H2,8,10)

InChi Key: ZLWYEPMDOUQDBW-UHFFFAOYSA-N