A-1210477 | B1826

A-1210477 is a potent MCL-1 inhibitor (Ki = 0.45 nM in TR-FRET-binding assays). Acts as a weak inhibitor of BCL-2 (Ki = 0.132 μM) and BCL-XL(Ki>0.660 μM).

A-1210477 is a potent MCL-1 inhibitor (Ki = 0.45 nM in TR-FRET-binding assays). Acts as a weak inhibitor of BCL-2 (Ki = 0.132 μM) and BCL-XL(Ki>0.660 μM).

B1826 | A-1210477 DataSheet

Alternate Name/Synonyms: 7-(5-((4-(4-(N,N-dimethylsulfamoyl)piperazin-1-yl)phenoxy)methyl)-1,3-dimethyl-1H-pyrazol-4-yl)-1-(2-morpholinoethyl)-3-(3-(naphthalen-1-yloxy)propyl)-1H-indole-2-carboxylic acid

Appearance: Crystalline solid

Formulation: N/A

CAS Number: 1668553-26-1

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: N/A

Molecular Formula: C₄₆H₅₅N₇O₇S

Molecular Weight: 850.04

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent MCL-1 inhibitor

MDL Number: N/A

PubChem CID: 66575373

SMILES: CC1=NN(C(=C1C2=CC=CC3=C2N(C(=C3CCCOC4=CC=CC5=CC=CC=C54)C(=O)O)CCN6CCOCC6)COC7=CC=C(C=C7)N8CCN(CC8)S(=O)(=O)N(C)C)C

InChi: InChI=1S/C46H55N7O7S/c1-33-43(41(49(4)47-33)32-60-36-19-17-35(18-20-36)51-22-24-52(25-23-51)61(56,57)48(2)3)40-14-8-13-38-39(15-9-29-59-42-16-7-11-34-10-5-6-12-37(34)42)45(46(54)55)53(44(38)40)26-21-50-27-30-58-31-28-50/h5-8,10-14,16-20H,9,15,21-32H2,1-4H3,(H,54,55)

InChi Key: XMVAWGSQPHFXKU-UHFFFAOYSA-N