AC-186 | B2980

AC-186 is a potent and selective estrogen receptor β (ERβ) agonist. It shows EC₅₀ values of 6 and 5000 nM for ERβ and ERα respectively in functional assays. Decrease in the sex steroids is associated with increased risk of Alzheimer’s disease. AC-186 exhibits gender selective neuroprotection in male animals in a rat model of Parkinson’s disease. AC-186 in combination with ACP-105 increases the amyloid-β degrading enzymes neprilysin and insulin-degrading enzyme, decreases amyloid-β levels in the brain as well as improves cognition in a mouse model of Alzheimer’s Disease.

AC-186 is a potent and selective estrogen receptor β (ERβ) agonist. It shows EC₅₀ values of 6 and 5000 nM for ERβ and ERα respectively in functional assays. Decrease in the sex steroids is associated with increased risk of Alzheimer’s disease. AC-186 exhibits gender selective neuroprotection in male animals in a rat model of Parkinson’s disease. AC-186 in combination with ACP-105 increases the amyloid-β degrading enzymes neprilysin and insulin-degrading enzyme, decreases amyloid-β levels in the brain as well as improves cognition in a mouse model of Alzheimer’s Disease.

B2980 | AC-186 DataSheet

Alternate Name/Synonyms: 4-[4,4-difluoro-1-(2-fluorophenyl)cyclohexyl]phenol

Appearance: Solid

Formulation:

CAS Number: 1421854-16-1

Structure Available?: True

Peptide sequence:

Salt Form: false

Molecular Formula: C₁₈H₁₇F₃O

Molecular Weight: 306.32

Cell-Permeable?: True

Purity: 95%

Solubilities: ~30 mg/ml in in DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A potent ERβ agonist

MDL Number:

PubChem CID: 71245042

SMILES: C1CC(CCC1(C2=CC=C(C=C2)O)C3=CC=CC=C3F)(F)F

InChi: InChI=1S/C18H17F3O/c19-16-4-2-1-3-15(16)17(9-11-18(20,21)12-10-17)13-5-7-14(22)8-6-13/h1-8,22H,9-12H2

InChi Key: HSMUKSLNDJOZQG-UHFFFAOYSA-N