Ac-WEHD-AFC | B2214

Ac-WEHD-AFC is a useful fluorogenic substrate for group I caspases (caspase-1, -4, and -5). Caspase activity can be quantified by fluorescent detection of free AFC that has an excitation maximum at 400 nm and emission maximum at 505 nm.

Ac-WEHD-AFC is a useful fluorogenic substrate for group I caspases (caspase-1, -4, and -5). Caspase activity can be quantified by fluorescent detection of free AFC that has an excitation maximum at 400 nm and emission maximum at 505 nm.

B2214 | Ac-WEHD-AFC DataSheet

Alternate Name/Synonyms: Caspase-1 substrate (fluorogenic), Caspase-5 substrate (fluorogenic)

Appearance: White to yellow solid

Formulation: N/A

CAS Number: 210344-99-3

Structure Available?: Yes

Peptide sequence: Ac-Trp-Glu-His-Asp-AFC

Salt Form: No

Molecular Formula: C₃₈H₃₇F₃N₈O₁₁

Molecular Weight: 838.8

Cell-Permeable?: Yes

Purity: ≥97% by HPLC

Solubilities: DMSO

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A Group I caspase substrate

MDL Number: N/A

PubChem CID: 25108578

SMILES: CC(=O)NC(CC1=CNC2=CC=CC=C21)C(=O)NC(CCC(=O)O)C(=O)NC(CC3=CN=CN3)C(=O)NC(CC(=O)O)C(=O)NC4=CC5=C(C=C4)C(=CC(=O)O5)C(F)(F)F

InChi: InChI=1S/C38H37F3N8O11/c1-18(50)45-27(10-19-15-43-25-5-3-2-4-22(19)25)36(58)47-26(8-9-31(51)52)34(56)48-28(11-21-16-42-17-44-21)37(59)49-29(14-32(53)54)35(57)46-20-6-7-23-24(38(39,40)41)13-33(55)60-30(23)12-20/h2-7,12-13,15-17,26-29,43H,8-11,14H2,1H3,(H,42,44)(H,45,50)(H,46,57)(H,47,58)(H,48,56)(H,49,59)(H,51,52)(H,53,54)/t26-,27-,28-,29-/m0/s1

InChi Key: NEGOLAGPKZGIKJ-DZUOILHNSA-N