Activated Protein C, Human Plasma | 7683

The Activated Human Protein C was activated from homogeneous protein C by activation with purified alpha-thrombin. The alpha-thrombin is removed after activation. Complete activation is observed on SDS-PAGE. Protein C (PROC) is a vitamin K-dependent serine protease which regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids. PROC is cleaved to its activated form by the thrombin-thrombomodulin complex. This activated form, which contains a serine protease domain, functions in degradation of the activated forms of coagulation factors V and VIII. Mutations in the PROC gene are linked with thrombophilia due to protein C deficiency, neonatal purpura fulminans, and recurrent venous thrombosis. This protein is purified from fresh frozen human plasma using a combination of salt precipitations and column chromatography.

7683 | Activated Protein C Human Plasma DataSheet

Biomolecule/Target: Activated Protein C

Synonyms: Vitamin K-dependent protein C, Anticoagulant protein C, Autoprothrombin IIA, Blood coagulation factor XIV, PROC, PC, APC, PROC1, THPH3, THPH4.

Alternates names: Vitamin K-dependent protein C, Anticoagulant protein C, Autoprothrombin IIA, Blood coagulation factor XIV, PROC, PC, APC, PROC1, THPH3, THPH4.

Taglines: Regulates blood coagulation by inactivating factors Va and VIIIa

NCBI Gene ID #: 5624

NCBI Gene Symbol: PROC

Gene Source: Human

Accession #: P04070

Recombinant: No

Source: Human Plasma

Purity by SDS-PAGEs: 95%

Assay: SDS-PAGE

Purity: N/A

Assay #2: N/A

Endotoxin Level: N/A

Activity (Specifications/test method): N/A

Biological activity: Lot dependent

Results: Lot dependent

Binding Capacity: N/A

Unit Definition: N/A

Molecular Weight: 56 kDa

Concentration: N/A

Appearance: Liquid

Physical form description: In 20 mM Tris-HCl, 0.1 M NaCl, pH 7.4

Reconstitution Instructions: N/A

Amino acid sequence: N/A