Protein C, Human Plasma | 7682

Protein C (PROC) is a vitamin K-dependent serine protease which regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids. PROC is cleaved to its activated form by the thrombin-thrombomodulin complex. This activated form, which contains a serine protease domain, functions in degradation of the activated forms of coagulation factors V and VIII. Mutations in the PROC gene are linked with thrombophilia due to protein C deficiency, neonatal purpura fulminans, and recurrent venous thrombosis. This protein is purified from fresh frozen human plasma using a combination of salt precipitations and column chromatography.

7682 | Protein C Human Plasma DataSheet

Biomolecule/Target: Protein C

Synonyms: Vitamin K-dependent protein C, Anticoagulant protein C, Autoprothrombin IIA, Blood coagulation factor XIV, PROC, PC, APC, PROC1, THPH3, THPH4.

Alternates names: Vitamin K-dependent protein C, Anticoagulant protein C, Autoprothrombin IIA, Blood coagulation factor XIV, PROC, PC, APC, PROC1, THPH3, THPH4.

Taglines: Regulates blood coagulation by inactivating factors Va and VIIIa

NCBI Gene ID #: 6352

NCBI Gene Symbol: TCP228

Gene Source: Human

Accession #: P13501

Recombinant: No

Source: Human Plasma

Purity by SDS-PAGEs: 98%

Assay: SDS-PAGE

Purity: N/A

Assay #2: N/A

Endotoxin Level: N/A

Activity (Specifications/test method): N/A

Biological activity: Determined by its ability to chemoattract human blood monocytes using a concentration range of 1-10 ng/ml.

Results: N/A

Binding Capacity: N/A

Unit Definition: N/A

Molecular Weight: 62 kDa

Concentration: N/A

Appearance: Liquid

Physical form description: In 20 mM Tris-HCl, 0.1 M NaCl, 1 mM Benzamidine -pH 7.4

Reconstitution Instructions: Reconstitute in HO to a concentration of 0.1-1 µg/µl. This solution can then be diluted into other aqueous buffers and stored at 4°C for 1 week or –20°c for future use.

Amino acid sequence: N/A