Active EIF2AK3, Human Recombinant | P1737

EIF2AK3 (Eukaryotic Translation Initiation Factor 2 Alpha Kinase 3), also known as PERK, is a metabolic-stress sensing protein kinase that phosphorylates and inactivates the alpha subunit of eukaryotic translation initiation factor 2 in response to various stress conditions. The action of EIF2AK3 directly results in a rapid reduction of translational initiation and protein synthesis. EIF2AK3 acts in response to various stress conditions such as low amino acid availability and misfolded proteins, and is thought to control mitochondrial morphology and function. Mutations in EIF2AK3 are associated with Wolcott-Rallison syndrome.

P1737 | Active EIF2AK3, Human Recombinant DataSheet

Biomolecule/Target :

Synonyms: Eukaryotic Translation Initiation Factor 2 Alpha Kinase 3; PERK; PEK; HsPEK; WRS

Alternates names: Eukaryotic Translation Initiation Factor 2 Alpha Kinase 3; PERK; PEK; HsPEK; WRS

Taglines: Key protein in cellular response to metabolic stresses

NCBI Gene ID #: 9451

NCBI Gene Symbol:

Gene Source: Human

Accession #: Q9NZJ5

Recombinant: True

Source: E.coli

Purity by SDS-PAGE: ≥ 70% by SDS-PAGE

Assay:

Purity:

Assay #2:

Endotoxin Level:

Activity (Specifications/test method): ≥ 15 nmol/min/mg as determined by the incorporation of Phosphorus-33-containing ATP into a SMAD3 protein substrate

Biological activity:

Results:

Binding Capacity:

Unit Definition:

Molecular Weight: 125 kDa (calculated); 115 kDa (observed)

Concentration:

Appearance: Sterile Filtered colorless solution

Physical form description: Liquid

Reconstitution Instructions:

Amino acid sequence: Amino acids 563 to 1115 with N-terminal GST tag

Handling: Centrifuge the vial prior to opening.

Usage: For Research Use Only! Not to be used in humans