AF/LE Purified Anti-Human CD279/PD-1 Antibody[J110] | E-AB-F12130

AF/LE Purified Anti-Human CD279/PD-1 Antibody[J110] | E-AB-F12130 | Gentaur UK, US & Europe Distribution

Category: Flow Cytometry Antibody

Synonyms: PDCD1,PD1,Protein PD-1,hPD-1

Swissprot Code: P20701

Application: FCM

Reactivity: Human

Host: Mouse

Isotype: Mouse IgG1, κ

Reaserch Area: Cancer, Cell Biology, Immunology

Background: Programmed cell death 1 (PD-1), also known as CD279, is a 55 kD member of the immunoglobulin superfamily. CD279 contains the immunoreceptor tyrosine-based inhibitory motif (ITIM) in the cytoplasmic region and plays a key role in peripheral tolerance and autoimmune disease. CD279 is expressed predominantly on activated T cells, B cells, and myeloid cells. PD-L1 and PD-L2 are ligands of CD279 (PD-1) and are members of the B7 gene family. Evidence suggests overlapping functions for these two PD-1 ligands and their constitutive expression on some normal tissues and upregulation on activated antigen-presenting cells. Interaction of CD279 ligands results in inhibition of T cell proliferation and cytokine secretion.

Concentration: 0.5 mg/mL

Storage: Store at 2~8°C. Do not freeze.

Immunogen: N/A

Purification Method: N/A

Dilution: N/A

Clone: J110

Conjugation: None (Purified antibody-Azide Free/Low endotoxin)