AF/LE Purified Anti-Human/Mouse/Rat CD47 Monoclonal Antibody | DL20293F

AF/LE Purified Anti-Human/Mouse/Rat CD47 Monoclonal Antibody | DL20293F | Gentaur UK, US & Europe Distribution

Host: Mouse

Synonyms: Leukocyte surface antigen CD47, Cd47, Integrin-associated protein, IAP

Reactivity: Human, Mouse, Rat

Application: FCM, WB, IH, IP, ICC&IF

Background: CD47, also known as Integrin-Associated Protein (IAP), is a membrane protein of about 50 kD with an IgV-like extracelluluar domain, a five membrane-spanning segment and a short terminal cytoplasmic region. It is widely expressed on many cell types and often associated with beta 3 integrins. It has been reported that CD47 functions as a self marker. Red cells lacking CD47 were rapidly cleared from the bloodstream by splenic macrophages. By binding to SIRPα, CD47 controls hemostatic innate immune functions, such as phagocytosis and cell trafficking.

Concentration: 0.2 mg/mL

Conjugation: None (Purified antibody, Azide Free/Low endotoxin)

Buffer: 0.2 μm filtered in PBS, pH7.2. Azide Free (AF) /Low Endotoxin (LE) : Contains no stabilizers or preservatives. Endotoxin level is < 2 EU/mg ( < 0.002EU/μg) as Determined by LAL gel clotting assay.

Clone: MIAP410

Isotype: Mouse IgG1, κ