Aftin-4 | 2574

A Roscovitine-related purine derivative that selectively and potently increases production of extracellular Aβ42 and decreases production of extracellular Aβ38 in cultured cells. Extracellular Aβ40 levels remain stable. Intracellular levels of these amyloids appear to remain stable. Alzheimer's Disease (AD) accelerator that interacts with VDAC1, prohibitin and mitofilin, possibly interfering with subcellular compartmentalization and lipid rafts properties, shifting γ-secretase activity toward Aβ42 generation. Induces a reversible mitochondrial phenotype reminiscent of the one observed in AD brains.

Aftin-4 is a Roscovitine-related purine derivative that selectively and potently increases production of extracellular Aβ42 and decreases production of extracellular Aβ38 in cultured cells. Extracellular Aβ40 levels remain stable. Intracellular levels of these amyloids appear to remain stable.

2574 | Aftin-4 DataSheet

Alternate Name/Synonyms: N6-Methyl-(R)-roscovitine; Amyloid-β Forty-Two Inducer 4

Appearance: White to off-white solid

Formulation: N/A

CAS Number: 866893-90-5

Structure Available?: Y

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₀H₂₈N₆O

Molecular Weight: 368.48

Cell-Permeable?: Yes

Purity: ≥98% by NMR

Solubilities: DMSO or EtOH

Handling: Protect from air and light

Country of Origin: USA

Tag Line: An amyloid-β42 Inducer

MDL Number: N/A

PubChem CID: N/A

SMILES: CC[C@H](CO)NC1=NC(N(C)CC2=CC=CC=C2)=C3C(N(C(C)C)C=N3)=N1

InChi: InChI=1S/C20H28N6O/c1-5-16(12-27)22-20-23-18(25(4)11-15-9-7-6-8-10-15)17-19(24-20)26(13-21-17)14(2)3/h6-10,13-14,16,27H,5,11-12H2,1-4H3,(H,22,23,24)/t16-/m1/s1

InChi Key: YPYWONAECUVKHY-MRXNPFEDSA-N