Description
Roscovitine-related purine with no activity on CDKS. Selectively and potently increases production of extracellular Aβ42 and decreases production of extracellular Aβ38 in cultured cells. Extracellular Aβ40 levels remain stable. Intracellular levels of these amyloids appear to remain stable. Alzheimer's Disease (AD) accelerator that interacts with VDAC1, prohibitin and mitofilin, possibly interfering with subcellular compartmentalization and lipid rafts properties, shifting γ-secretase activity toward Aβ42 generation. Induces a reversible mitochondrial phenotype reminiscent of the one observed in AD brains.
Aftin-5 is a Roscovitine-related purine with no activity on CDKS. Selectively and potently increases production of extracellular Aβ42 and decreases production of extracellular Aβ38 in cultured cells. Extracellular Aβ40 levels remain stable. Intracellular levels of these amyloids appear to remain stable.
Alternate Name/Synonyms: (2R)-2-[[9-Isopropyl-6-(N-methylanilino)purin-2-yl]amino]butan-1-ol; Amyloidβ Forty-Two Inducer 5
Appearance: White to off-white solid
Formulation: N/A
CAS Number: N/A
Structure Available?: Y
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₁₉H₂₆N₆O
Molecular Weight: 354.45
Cell-Permeable?: Yes
Purity: ≥98% by NMR
Solubilities: DMSO or EtOH
Handling: Protect from air and light
Country of Origin: USA
Tag Line: An amyloid-β42 Inducer
MDL Number: N/A
PubChem CID: N/A
SMILES: CC(C)N1C2=NC(N[C@@H](CO)CC)=NC(N(C)C3=CC=CC=C3)=C2N=C1
InChi: InChI=1S/C19H26N6O/c1-5-14(11-26)21-19-22-17(24(4)15-9-7-6-8-10-15)16-18(23-19)25(12-20-16)13(2)3/h6-10,12-14,26H,5,11H2,1-4H3,(H,21,22,23)/t14-/m1/s1
InChi Key: HYFZLABHJHEEFS-CQSZACIVSA-N
Additional Information
Storage Condition: |
-20°C |
Shipping Condition: |
Gel Pack |
Shelf Life: |
24 months |