AG-14361 | B2175

AG-14361 is a potent and selective inhibitor of PARP-1 with Ki value of <5 nM in a cell-free assay. AG-14361 sensitizes cells to topoisomerase I poisons by increasing the persistence of DNA strand breaks.

AG-14361 is a potent and selective inhibitor of PARP-1 with Ki value of <5 nM in a cell-free assay. AG-14361 sensitizes cells to topoisomerase I poisons by increasing the persistence of DNA strand breaks.

B2175 | AG-14361 DataSheet

Alternate Name/Synonyms: 1-(4-((dimethylamino)methyl)phenyl)-8,9-dihydro-2,7,9a-triazabenzo[cd]azulen-6(7H)-one

Appearance: Crystalline solid

Formulation: N/A

CAS Number: 328543-09-5

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₉H₂₀N₄O

Molecular Weight: 320.39

Cell-Permeable?: Yes

Purity: ≥98%

Solubilities: DMSO

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent PARP-1 inhibitor

MDL Number: N/A

PubChem CID: 9840076

SMILES: CN(C)CC1=CC=C(C=C1)C2=NC3=CC=CC4=C3N2CCNC4=O

InChi: InChI=1S/C19H20N4O/c1-22(2)12-13-6-8-14(9-7-13)18-21-16-5-3-4-15-17(16)23(18)11-10-20-19(15)24/h3-9H,10-12H2,1-2H3,(H,20,24)

InChi Key: SEKJSSBJKFLZIT-UHFFFAOYSA-N