Description
AG-14361 is a potent and selective inhibitor of PARP-1 with Ki value of <5 nM in a cell-free assay. AG-14361 sensitizes cells to topoisomerase I poisons by increasing the persistence of DNA strand breaks.
AG-14361 is a potent and selective inhibitor of PARP-1 with Ki value of <5 nM in a cell-free assay. AG-14361 sensitizes cells to topoisomerase I poisons by increasing the persistence of DNA strand breaks.
Alternate Name/Synonyms: 1-(4-((dimethylamino)methyl)phenyl)-8,9-dihydro-2,7,9a-triazabenzo[cd]azulen-6(7H)-one
Appearance: Crystalline solid
Formulation: N/A
CAS Number: 328543-09-5
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₁₉H₂₀N₄O
Molecular Weight: 320.39
Cell-Permeable?: Yes
Purity: ≥98%
Solubilities: DMSO
Handling: Protect from air and light
Country of Origin: USA
Tag Line: A potent PARP-1 inhibitor
MDL Number: N/A
PubChem CID: 9840076
SMILES: CN(C)CC1=CC=C(C=C1)C2=NC3=CC=CC4=C3N2CCNC4=O
InChi: InChI=1S/C19H20N4O/c1-22(2)12-13-6-8-14(9-7-13)18-21-16-5-3-4-15-17(16)23(18)11-10-20-19(15)24/h3-9H,10-12H2,1-2H3,(H,20,24)
InChi Key: SEKJSSBJKFLZIT-UHFFFAOYSA-N
Additional Information
Storage Condition: |
-20°C |
Shipping Condition: |
Gel Pack |
Shelf Life: |
36 months |