AGI-5198 | 2369

A potent, selective inhibitor of mutant IDH1 (isocitrate dehydrogenase 1). AGI-5198 inhibits IDH1 R132H and R132C mutants in vitro with IC₅₀ values of 0.07 and 0.16 µM, respectively, but not wild-type IDH1, wild-type IDH2, or IDH2 mutants (IC₅₀ s > 100 μM). Under conditions of near complete 2-HG (2-hydroxyglutarate) inhibition, AGI-5198 can induce demethylation of histone H3K9me3 and expression

AGI-5198 is a potent, selective inhibitor of mutant IDH1 (isocitrate dehydrogenase 1).

2369 | AGI-5198 DataSheet

Alternate Name/Synonyms: N-​[2-​(cyclohexylamino)-​1-​(2-​methylphenyl)-​2-​oxoethyl]-​N-​(3-​fluorophenyl)-​2-​methyl-​1H-​imidazole-​1-​acetamide; IDH-C35

Appearance: Crystalline solid

Formulation: N/A

CAS Number: 1355326-35-0

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₇H₃₁FN₄O₂

Molecular Weight: 462.56

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (~25 mg/ml) or Ethanol (~ 15 mg/ml)

Handling: Protect from light and moisture

Country of Origin: USA

Tag Line: A potent, selective inhibitor of mutant IDH1 (isocitrate dehydrogenase 1)

MDL Number: N/A

PubChem CID: 56645356

SMILES: CC1=CC=CC=C1C(C(=O)NC2CCCCC2)N(C3=CC(=CC=C3)F)C(=O)CN4C=CN=C4C

InChi: InChI=1S/C27H31FN4O2/c1-19-9-6-7-14-24(19)26(27(34)30-22-11-4-3-5-12-22)32(23-13-8-10-21(28)17-23)25(33)18-31-16-15-29-20(31)2/h6-10,13-17,22,26H,3-5,11-12,18H2,1-2H3,(H,30,34)

InChi Key: FNYGWXSATBUBER-UHFFFAOYSA-N