Description
A potent, selective inhibitor of mutant IDH1 (isocitrate dehydrogenase 1). AGI-5198 inhibits IDH1 R132H and R132C mutants in vitro with IC₅₀ values of 0.07 and 0.16 µM, respectively, but not wild-type IDH1, wild-type IDH2, or IDH2 mutants (IC₅₀ s > 100 μM). Under conditions of near complete 2-HG (2-hydroxyglutarate) inhibition, AGI-5198 can induce demethylation of histone H3K9me3 and expression
AGI-5198 is a potent, selective inhibitor of mutant IDH1 (isocitrate dehydrogenase 1).
Alternate Name/Synonyms: N-[2-(cyclohexylamino)-1-(2-methylphenyl)-2-oxoethyl]-N-(3-fluorophenyl)-2-methyl-1H-imidazole-1-acetamide; IDH-C35
Appearance: Crystalline solid
Formulation: N/A
CAS Number: 1355326-35-0
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₂₇H₃₁FN₄O₂
Molecular Weight: 462.56
Cell-Permeable?: Yes
Purity: ≥98% by HPLC
Solubilities: DMSO (~25 mg/ml) or Ethanol (~ 15 mg/ml)
Handling: Protect from light and moisture
Country of Origin: USA
Tag Line: A potent, selective inhibitor of mutant IDH1 (isocitrate dehydrogenase 1)
MDL Number: N/A
PubChem CID: 56645356
SMILES: CC1=CC=CC=C1C(C(=O)NC2CCCCC2)N(C3=CC(=CC=C3)F)C(=O)CN4C=CN=C4C
InChi: InChI=1S/C27H31FN4O2/c1-19-9-6-7-14-24(19)26(27(34)30-22-11-4-3-5-12-22)32(23-13-8-10-21(28)17-23)25(33)18-31-16-15-29-20(31)2/h6-10,13-17,22,26H,3-5,11-12,18H2,1-2H3,(H,30,34)
InChi Key: FNYGWXSATBUBER-UHFFFAOYSA-N
Additional Information
Storage Condition: |
-20 ̊C |
Shipping Condition: |
Gel Pack |
Shelf Life: |
36 months |