Aloxistatin [E-64d] | 11-077

Aloxistatin [E-64d] | 11-077 | Gentaur UK, US & Europe Distribution

BNR: Chemical

Predicted Molecular Weight: 342, 4

Physical State: Lyophilized

Storage Condition: Short Term Storage: +4C. Long Term Storage: -20C. Handling Advice: Keep cool and dry. Use/Stability: Stable for at least 2 years after receipt when stored at -20C.

Alternate Name: E-64c ethyl ester; EP 453; EST; Loxistatin

Background: Aloxistatin [E-64d] is a cell permeable irreversible inhibitor of lysosomal and cytosolic cysteine proteases cathepsin B an L, calpain 1/2, papain and has diverse biological activities. It is an ethyl ester form of E-64c that inhibits calpain and the cysteine proteases cathepsins F, K, B, H, and L. Aloxistatin has anticancer properties by inducing cell cycle arret at the G2/M phase in A431 human epidermoid carcinoma cells and as a lysosomal inhibitor in human acute promyelocytic leukemia NB4 cells and Huh-7 cells. It inhibits degradation of autophagic cargo inside autolysosomes. It also shows neuroprotective and anti-malarial properties. Since cysteine protease cathepsin L is required for SARS-CoV-2 viral entry, aloxistatin treatment reduces cellular entry of SARS-CoV-2 pseudovirions and COVID-19. It inhibits severe acute respiratory syndrome coronavirus (SARS-CoV) and SARS-CoV-2 surface glycoprotein incorporation into pseudotyped vesicular stomatitis virus (VSV) particles in Vero cells. Is has been applied in vitro in combination with the TMPRSS2 inhibitor camostat mesylate (Prod. No. AG-CR1-3716) .

Disclaimer: This product is for research use only.

Purity: greater than or equal to 95% (HPLC)

Formula: C17H30N2O5

Source: N/A

Solubility: Soluble in DMSO (20mg/ml), DMF (20mg/ml) or ethanol (5mg/ml) .

InChi Key: SRVFFFJZQVENJC-IHRRRGAJSA-N

Smiles: O=C (OCC) [C@H]1O[C@@H]1C (N[C@H] (C (NCCC (C) C) =O) CC (C) C) =O

RTECS: RR0404300

Identity: Determined by 1H-NMR.

Merck Index: N/A