E-64d | B3057

E-64d is a synthetic analog of E-64 which is a membrane permeable inhibitor of lysosomal and cytosolic cysteine proteases. It inhibits cathepsins B and L in intact lysosomes and cells. It (20-200 µg/ml) induces cell cycle arrest at the G2/M phase in A431 human epidermoid carcinoma cells. E-64d inhibits the entry of SARS-Cov-2 into Caco-2 cells in combination with Camostat mesylate.

E-64d is a synthetic analog of E-64 which is a membrane permeable inhibitor of lysosomal and cytosolic cysteine proteases. It inhibits cathepsins B and L in intact lysosomes and cells. It (20-200 µg/ml) induces cell cycle arrest at the G2/M phase in A431 human epidermoid carcinoma cells. E-64d inhibits the entry of SARS-Cov-2 into Caco-2 cells in combination with Camostat mesylate.

B3057 | E-64d DataSheet

Alternate Name/Synonyms: Aloxistatin; Loxistatin; ethyl (2S,3S)-3-[[(2S)-4-methyl-1-(3-methylbutylamino)-1-oxopentan-2-yl]carbamoyl]oxirane-2-carboxylate; ethyl (+)-(2S,3S)-2,3-epoxy-N-((S)-1-(isopentylcarbamoyl)-3-methylbutyl)succinamate; (2S,3S)-ethyl 3-(((S)-1-(isopentylamino)-4-methyl-1-oxopentan-2-yl)carbamoyl)oxirane-2-carboxylate

Appearance: White to off-white solid powder

Formulation:

CAS Number: 88321-09-9

Structure Available?: TRUE

Peptide sequence:

Salt Form: FALSE

Molecular Formula: C₁₇H₃₀N₂O₅

Molecular Weight: 342.43

Cell-Permeable?: FALSE

Purity: ≥98%

Solubilities: ~30 mg/ml in DMSO and DMF; ~10 mg/ml in ethanol

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A membrane permeable inhibitor of lysosomal and cytosolic cysteine proteases

MDL Number: MFCD00132883

PubChem CID: 65663

SMILES: CCOC(=O)C1C(O1)C(=O)NC(CC(C)C)C(=O)NCCC(C)C

InChi: InChI=1S/C17H30N2O5/c1-6-23-17(22)14-13(24-14)16(21)19-12(9-11(4)5)15(20)18-8-7-10(2)3/h10-14H,6-9H2,1-5H3,(H,18,20)(H,19,21)/t12-,13-,14-/m0/s1

InChi Key: SRVFFFJZQVENJC-IHRRRGAJSA-N