Alpha 2 Macroglobulin, Human Plasma, Fast Form | 7297

Alpha 2 Macroglobulin (A2M) is a plasma protease inhibitor which has been shown to exist in two forms. The Slow Form of A2M (S-A2M) is the form which possesses the ability to bind and inhibit proteases by a “trap” method. The Fast Form of A2M (F-A2M) is generated when S-A2M undergoes a conformational change due to either entrapment of a protease in the A2M bait region, or chemical cleavage of an internal thiol ester bond located near the bait region. F-A2M does not possess the ability to bind and inhibit protease activity. F-A2M is rapidly taken up by the liver, with a half-life of 2-4 minutes. In vivo, F-A2M typically represents only 0.17–0.7% of the total A2M in blood plasma of adults. The F-A2M plasma concentration is, however, increased in many disease states including pancreatitis, multiple sclerosis and sepsis. F-A2M has also been implicated in the inhibition of amyloid formation associated with Alzheimer’s disease and spongiform encephalopathy.

7297 | Alpha 2 Macroglobulin Human Plasma Fast Form DataSheet

Biomolecule/Target: Alpha 2 Macroglobulin

Synonyms: C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5, A2M, CPAMD5, FWP007

Alternates names: C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5, A2M, CPAMD5, FWP007

Taglines: A broad-spectrum protease-binding protein

NCBI Gene ID #: 2

NCBI Gene Symbol: A2M

Gene Source: Human

Accession #: P01023

Recombinant: No

Source: Human Plasma

Purity by SDS-PAGEs: 95%

Assay: SDS-PAGE

Purity: N/A

Assay #2: N/A

Endotoxin Level: N/A

Activity (Specifications/test method): N/A

Biological activity: N/A

Results: N/A

Binding Capacity: N/A

Unit Definition: N/A

Molecular Weight: 725 kDa (Homotetramer, Subunit size: 180 kDa)

Concentration: N/A

Appearance: Lyophilized

Physical form description: Lyophilized from 100 mM Na Phosphate, pH 7.2.

Reconstitution Instructions: In water or aqueous buffer

Amino acid sequence: N/A