Anti- Adenylosuccinate lyase Antibody | FNab00161

Anti- Adenylosuccinate lyase Antibody | FNab00161 | Gentaur UK, US & Europe Distribution

Form: liquid

Purification: Immunogen affinity purified

Purity: ≥95% as determined by SDS-PAGE

Host: Rabbit

Clonality: polyclonal

Clone ID: N/A

Isotype: IgG

Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)

Background: ADSL (adenylosuccinate lyase) is also named as AMPS, ASase, ASL and belongs to the lyase 1 family. It is an enzyme involved in 2 pathways of purine nucleotide metabolism and catalyzes cleavage of succinyl groups to yield fumarate (PMID:18524658) . Defects in ADSL are the cause of adenylosuccinase deficiency (ADSL deficiency) . In humans, mutations in ADSL lead to an inborn error of metabolism originally characterized by developmental delay, often with autistic features (PMID:20884265) ..The ADSL enzymatic activity is reduced in lymphocytes and red blood cells of the patient with severe psychomotor retardation (PMID:9545543) . It has 2 isoforms produced by alternative splicing.

Immunogen: adenylosuccinate lyase

synonyms: Adenylosuccinase, adenylosuccinate lyase, ADSL, AMPS, ASASE, ASL

Molecular weight (observed) : 55 kDa

Reactivity Species: Human, Mouse, Rat

Tested Application: ELISA, WB, IHC

Recomended Dillution : WB: 1:500-1:5000; IHC: 1:20-1:200; IF: 1:10-1:100

Research Area: Metabolism