710
Anti- ALKBH7 Antibody | FNab00315
- SKU:
- 710-FNab00315-GEN
- Availability:
- In Stock - Delivery within a week
Description
Anti- ALKBH7 Antibody | FNab00315 | Gentaur UK, US & Europe Distribution
Form: liquid
Purification: Immunogen affinity purified
Purity: ≥95% as determined by SDS-PAGE
Host: Rabbit
Clonality: polyclonal
Clone ID: N/A
Isotype: IgG
Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)
Background: May function as protein hydroxylase; can catalyze auto-hydroxylation at Leu-110 (in vitro), but this activity may be due to the absence of the true substrate (PubMed:25122757) . Required to induce programmed necrosis in response to DNA damage caused by cytotoxic alkylating agents. Acts by triggering the collapse of mitochondrial membrane potential and loss of mitochondrial function that leads to energy depletion and cell death (PubMed:23666923) . ALKBH7-mediated necrosis is probably required to prevent the accumulation of cells with DNA damage (PubMed:23666923) . Does not display DNA demethylase activity (PubMed:23666923) . Involved in fatty acid metabolism (By similarity) .
Immunogen: alkB, alkylation repair homolog 7 (E. coli)
synonyms: ABH7, ALKBH7, SPATA11, UNQ6002
Molecular weight (observed) : 25 kDa
Reactivity Species: Human, Mouse, Rat
Tested Application: ELISA, WB
Recomended Dillution : WB: 1:200-1:2000; IHC: 1:20-1:200
Research Area: Metabolism