Anti- ALKBH7 Antibody | FNab00315

Anti- ALKBH7 Antibody | FNab00315 | Gentaur UK, US & Europe Distribution

Form: liquid

Purification: Immunogen affinity purified

Purity: ≥95% as determined by SDS-PAGE

Host: Rabbit

Clonality: polyclonal

Clone ID: N/A

Isotype: IgG

Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)

Background: May function as protein hydroxylase; can catalyze auto-hydroxylation at Leu-110 (in vitro), but this activity may be due to the absence of the true substrate (PubMed:25122757) . Required to induce programmed necrosis in response to DNA damage caused by cytotoxic alkylating agents. Acts by triggering the collapse of mitochondrial membrane potential and loss of mitochondrial function that leads to energy depletion and cell death (PubMed:23666923) . ALKBH7-mediated necrosis is probably required to prevent the accumulation of cells with DNA damage (PubMed:23666923) . Does not display DNA demethylase activity (PubMed:23666923) . Involved in fatty acid metabolism (By similarity) .

Immunogen: alkB, alkylation repair homolog 7 (E. coli)

synonyms: ABH7, ALKBH7, SPATA11, UNQ6002

Molecular weight (observed) : 25 kDa

Reactivity Species: Human, Mouse, Rat

Tested Application: ELISA, WB

Recomended Dillution : WB: 1:200-1:2000; IHC: 1:20-1:200

Research Area: Metabolism