26
Anti-HIPK3 Antibody | A2280
- SKU:
- 26-A2280-100-GEN
- Availability:
- Usually shipped in 5 working days
Description
Homeodomain-Interacting Protein Kinase 3 (HIPK3) is a serine/threonine kinase that belongs to the family of Homeodomain-Interacting Protein Kinase. It plays an important in multiple cellular processes such as proliferation, DNA-damage response, oxidative stress, and development. It is also involved in the regulation of transcription, apoptosis, and expression of steroidogenic genes. It is highly expressed in the heart and skeletal muscle but lowly expressed in other tissues such as the pancreas, brain, spleen, thymus, testis, small intestine, and colon. It is found overexpressed in multidrug-resistant cells. Knockdown of HIPK3 in mice leads to glucose intolerance, impaired insulin secretion, and increased apoptosis of the pancreatic ?-cells. Recent studies have demonstrated that circular RNA of HIPK3 is expressed in multiple diseases such as diabetes, cancer, age-related cataract, and idiopathic pulmonary fibrosis and may serve as a promising biomarker to study disease development and progression
A2280 | Anti-HIPK3 Antibody DataSheet
Antibody Target: HIPK3
Target Alternative Name: PKY, YAK1, DYRK6, FIST3, HIPK3, EC 2.7.11.1, ANPK, FIST
Tag Line: Rabbit polyclonal antibody to detect HIPK3 expression in human samples
Category: Primary antibody
Host: Rabbit
Isotype: IgG
Species Reactivities: Human
Immunogen Sequence: Recombinant Human HIPK3 protein (aa 841-1130)
Accession #: Q9H422
Gene ID: 10114
Appearance: Colorless liquid
Form: Liquid
Concentration:
Formulation: In 0.01 M PBS, pH 7.4, 50% Glycerol, 0.03% proclin 300
Purification: Protein G purified
Application: Immunofluorescence (IF) Immunohistochemistry (IHC)
Positive Control:
Application And Usages: IHC (1:20-1:200), IF (1:50-1:200)
Country of Animal Origin: USA
Country of Manufacture: USA
Usage: For Research Use Only! Not to be used in humans.
Handling: The antibody solution should be gently mixed before use.
Western Blot Verified: FALSE
Immunocytochemistry Verified: FALSE
Immunofluorescence Verified: FALSE
Immunoprecipitation Verified: TRUE
FACS Verified: FALSE
ELISA Verified: FALSE
ChIP Verified: TRUE
Dot Blot Verified: FALSE
Flow Cytometry Verified: FALSE
Additional Information
Size: |
100 ug |
Storage Condition: |
-20°C |
Shipping Condition: |
Gel Pack |
Shelf Life: |
12 months |