Anti-HIPK3 Antibody | A2280

Homeodomain-Interacting Protein Kinase 3 (HIPK3) is a serine/threonine kinase that belongs to the family of Homeodomain-Interacting Protein Kinase. It plays an important in multiple cellular processes such as proliferation, DNA-damage response, oxidative stress, and development. It is also involved in the regulation of transcription, apoptosis, and expression of steroidogenic genes. It is highly expressed in the heart and skeletal muscle but lowly expressed in other tissues such as the pancreas, brain, spleen, thymus, testis, small intestine, and colon. It is found overexpressed in multidrug-resistant cells. Knockdown of HIPK3 in mice leads to glucose intolerance, impaired insulin secretion, and increased apoptosis of the pancreatic ?-cells. Recent studies have demonstrated that circular RNA of HIPK3 is expressed in multiple diseases such as diabetes, cancer, age-related cataract, and idiopathic pulmonary fibrosis and may serve as a promising biomarker to study disease development and progression

A2280 | Anti-HIPK3 Antibody DataSheet

Antibody Target: HIPK3

Target Alternative Name: PKY, YAK1, DYRK6, FIST3, HIPK3, EC 2.7.11.1, ANPK, FIST

Tag Line: Rabbit polyclonal antibody to detect HIPK3 expression in human samples

Category: Primary antibody

Host: Rabbit

Isotype: IgG

Species Reactivities: Human

Immunogen Sequence: Recombinant Human HIPK3 protein (aa 841-1130)

Accession #: Q9H422

Gene ID: 10114

Appearance: Colorless liquid

Form: Liquid

Concentration:

Formulation: In 0.01 M PBS, pH 7.4, 50% Glycerol, 0.03% proclin 300

Purification: Protein G purified

Application: Immunofluorescence (IF) Immunohistochemistry (IHC)

Positive Control:

Application And Usages: IHC (1:20-1:200), IF (1:50-1:200)

Country of Animal Origin: USA

Country of Manufacture: USA

Usage: For Research Use Only! Not to be used in humans.

Handling: The antibody solution should be gently mixed before use.

Western Blot Verified: FALSE

Immunocytochemistry Verified: FALSE

Immunofluorescence Verified: FALSE

Immunoprecipitation Verified: TRUE

FACS Verified: FALSE

ELISA Verified: FALSE

ChIP Verified: TRUE

Dot Blot Verified: FALSE

Flow Cytometry Verified: FALSE