710
Anti- HP Antibody | FNab03990
- SKU:
- 710-FNab03990-GEN
- Availability:
- In Stock - Delivery within a week
Description
Anti- HP Antibody | FNab03990 | Gentaur UK, US & Europe Distribution
Form: liquid
Purification: Protein A+G purification
Purity: ≥95% as determined by SDS-PAGE
Host: Mouse
Clonality: monoclonal
Clone ID: 7C8
Isotype: IgG2a
Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)
Background: As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an Antimicrobial; Antioxidant, has antibacterial activity and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidely cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pathway. Uncleaved haptoglogin, also known as zonulin, plays a role in intestinal permeability, allowing intercellular tight junction disassembly, and controlling the equilibrium between tolerance and immunity to non-self antigens.
Immunogen: haptoglobin
synonyms: BP, HAPT, haptoglobin, HP, HP2 ALPHA 2, HPA1S, Zonulin
Molecular weight (observed) : 42 kDa
Reactivity Species: Human, Pig
Tested Application: ELISA, WB
Recomended Dillution : WB: 1:2000 - 1:20000
Research Area: Cardiovascular, Stem Cells, Metabolism, Signal Transduction, Cancer