Anti- HP Antibody | FNab03990

Anti- HP Antibody | FNab03990 | Gentaur UK, US & Europe Distribution

Form: liquid

Purification: Protein A+G purification

Purity: ≥95% as determined by SDS-PAGE

Host: Mouse

Clonality: monoclonal

Clone ID: 7C8

Isotype: IgG2a

Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)

Background: As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an Antimicrobial; Antioxidant, has antibacterial activity and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidely cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pathway. Uncleaved haptoglogin, also known as zonulin, plays a role in intestinal permeability, allowing intercellular tight junction disassembly, and controlling the equilibrium between tolerance and immunity to non-self antigens.

Immunogen: haptoglobin

synonyms: BP, HAPT, haptoglobin, HP, HP2 ALPHA 2, HPA1S, Zonulin

Molecular weight (observed) : 42 kDa

Reactivity Species: Human, Pig

Tested Application: ELISA, WB

Recomended Dillution : WB: 1:2000 - 1:20000

Research Area: Cardiovascular, Stem Cells, Metabolism, Signal Transduction, Cancer