Anti-Human/Mouse/Rat Foxp3 Monoclonal Antibody (APC Conjugated) | DL22206F

Anti-Human/Mouse/Rat Foxp3 Monoclonal Antibody (APC Conjugated) | DL22206F | Gentaur UK, US & Europe Distribution

Host: Mouse

Synonyms: Forkhead box protein P3, IPEX, JM2, Foxp3

Reactivity: Human, Mouse, Rat

Application: ICFCM

Background: FOXP3 is a 50-55 kD transcription factor, also known as Forkhead box protein P3, Scurfin, JM2, or IPEX. It is proposed to be a master regulatory gene and more specific marker of T regulatory cells than most cell surface markers (such as CD4 and CD25) . Transduced expression of FOXP3 in CD4+/CD25- cells has been shown to induce GITR, CD103, and CTLA4 and impart a T regulatory cell phenotype. FOXP3 is mutated in X-linked autoimmunity-allergic dysregulation syndrome (XLAAD or IPEX) in humans and in "scurfy" mice. Overexpression of FOXP3 has been shown to lead to a hypoactive immune state suggesting that this transcriptional factor is a central regulator of T cell activity. In human, unlike in mouse, two isoforms of FOXP3 have been reported: one (FOXP3) corresponding to the canonical full-length sequence; the other (FOXP3 δ2) lacking exon 2. The 150D monoclonal antibody reacts with human, mouse and rat FOXP3. The 150D antibody recognizes FOXP3 epitope encoded by exon 2.

Concentration: N/A

Conjugation: APC

Buffer: PBS with 0.05% Proclin300, 1% BSA

Clone: 150D

Isotype: Mouse IgG1, κ