710
Anti- LARGE Antibody | FNab04697
- SKU:
- 710-FNab04697-GEN
- Availability:
- In Stock - Delivery within a week
Description
Anti- LARGE Antibody | FNab04697 | Gentaur UK, US & Europe Distribution
Form: liquid
Purification: Immunogen affinity purified
Purity: ≥95% as determined by SDS-PAGE
Host: Rabbit
Clonality: polyclonal
Clone ID: N/A
Isotype: IgG
Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)
Background: Bifunctional glycosyltransferase with both xylosyltransferase and beta-1, 3-glucuronyltransferase activities involved in the biosynthesis of the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-3-N-acetylglucosamine-beta-4- (phosphate-6-) mannose), a carbohydrate structure present in alpha-dystroglycan (DAG1) (PubMed:22223806) . Phosphorylated O-mannosyl trisaccharid is required for binding laminin G-like domain-containing extracellular proteins with high affinity and plays a key role in skeletal muscle function and regeneration. LARGE elongates the glucuronyl-beta-1, 4-xylose-beta disaccharide primer structure initiated by B3GNT1/B4GAT1 by adding repeating units [-3-Xylose-alpha-1, 3-GlcA-beta-1-] to produce a heteropolysaccharide (PubMed:25279699) .
Immunogen: like-glycosyltransferase
synonyms: KIAA0609, LARGE1
Molecular weight (observed) : 65-70 kDa
Reactivity Species: Human, Mouse
Tested Application: ELISA, WB, IF, IHC
Recomended Dillution : WB: 1:500-1:2000
Research Area: Metabolism