Anti- LARGE Antibody | FNab04697

Anti- LARGE Antibody | FNab04697 | Gentaur UK, US & Europe Distribution

Form: liquid

Purification: Immunogen affinity purified

Purity: ≥95% as determined by SDS-PAGE

Host: Rabbit

Clonality: polyclonal

Clone ID: N/A

Isotype: IgG

Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)

Background: Bifunctional glycosyltransferase with both xylosyltransferase and beta-1, 3-glucuronyltransferase activities involved in the biosynthesis of the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-3-N-acetylglucosamine-beta-4- (phosphate-6-) mannose), a carbohydrate structure present in alpha-dystroglycan (DAG1) (PubMed:22223806) . Phosphorylated O-mannosyl trisaccharid is required for binding laminin G-like domain-containing extracellular proteins with high affinity and plays a key role in skeletal muscle function and regeneration. LARGE elongates the glucuronyl-beta-1, 4-xylose-beta disaccharide primer structure initiated by B3GNT1/B4GAT1 by adding repeating units [-3-Xylose-alpha-1, 3-GlcA-beta-1-] to produce a heteropolysaccharide (PubMed:25279699) .

Immunogen: like-glycosyltransferase

synonyms: KIAA0609, LARGE1

Molecular weight (observed) : 65-70 kDa

Reactivity Species: Human, Mouse

Tested Application: ELISA, WB, IF, IHC

Recomended Dillution : WB: 1:500-1:2000

Research Area: Metabolism