710
Anti- MCM8 Antibody | FNab05063
- SKU:
- 710-FNab05063-GEN
- Availability:
- In Stock - Delivery within a week
Description
Anti- MCM8 Antibody | FNab05063 | Gentaur UK, US & Europe Distribution
Form: liquid
Purification: Immunogen affinity purified
Purity: ≥95% as determined by SDS-PAGE
Host: Rabbit
Clonality: polyclonal
Clone ID: N/A
Isotype: IgG
Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)
Background: Component of the MCM8-MCM9 complex, a complex involved in homologous recombination repair following DNA interstrand cross-links and plays a key role during gametogenesis. The MCM8-MCM9 complex probably acts as a hexameric helicase downstream of the Fanconi anemia proteins BRCA2 and RAD51 and is required to process aberrant forks into homologous recombination substrates and to orchestrate homologous recombination with resection, fork stabilization and fork restart. May also play a non-essential for DNA replication: may be involved in the activation of the prereplicative complex (pre-RC) during G (1) phase by recruiting CDC6 to the origin recognition complex (ORC) . Binds chromatin throughout the cell cycle.
Immunogen: minichromosome maintenance complex component 8
synonyms: C20orf154
Molecular weight (observed) : 95 kDa
Reactivity Species: Human, Mouse, Rat
Tested Application: ELISA, WB, IP, IHC
Recomended Dillution : WB: 1:500-1:2000
Research Area: Metabolism