Anti- MCM8 Antibody | FNab05063

Anti- MCM8 Antibody | FNab05063 | Gentaur UK, US & Europe Distribution

Form: liquid

Purification: Immunogen affinity purified

Purity: ≥95% as determined by SDS-PAGE

Host: Rabbit

Clonality: polyclonal

Clone ID: N/A

Isotype: IgG

Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)

Background: Component of the MCM8-MCM9 complex, a complex involved in homologous recombination repair following DNA interstrand cross-links and plays a key role during gametogenesis. The MCM8-MCM9 complex probably acts as a hexameric helicase downstream of the Fanconi anemia proteins BRCA2 and RAD51 and is required to process aberrant forks into homologous recombination substrates and to orchestrate homologous recombination with resection, fork stabilization and fork restart. May also play a non-essential for DNA replication: may be involved in the activation of the prereplicative complex (pre-RC) during G (1) phase by recruiting CDC6 to the origin recognition complex (ORC) . Binds chromatin throughout the cell cycle.

Immunogen: minichromosome maintenance complex component 8

synonyms: C20orf154

Molecular weight (observed) : 95 kDa

Reactivity Species: Human, Mouse, Rat

Tested Application: ELISA, WB, IP, IHC

Recomended Dillution : WB: 1:500-1:2000

Research Area: Metabolism