Anti- PPARA Antibody | FNab06663

Anti- PPARA Antibody | FNab06663 | Gentaur UK, US & Europe Distribution

Form: liquid

Purification: Immunogen affinity purified

Purity: ≥95% as determined by SDS-PAGE

Host: Rabbit

Clonality: polyclonal

Clone ID: N/A

Isotype: IgG

Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)

Background: Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC) . Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety. Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2. May be required for the propagation of clock information to metabolic pathways regulated by PER2.

Immunogen: peroxisome proliferator-activated receptor alpha

synonyms: hPPAR, NR1C1, PPAR, PPAR alpha, PPARA

Molecular weight (observed) : 52-55 kDa

Reactivity Species: Human

Tested Application: ELISA, WB, IF, IHC

Recomended Dillution : WB: 1:200-1:1000; IP: 1:200-1:1000 ; IHC: 1:50-1:200

Research Area: Signal Transduction, Metabolism, Cardiovascular, Developmental biology, Neuroscience