Anti-Pyruvate Carboxylase Antibody | A2020

This gene encodes pyruvate carboxylase, which requires biotin and ATP to catalyze the carboxylation of pyruvate to oxaloacetate. The active enzyme is a homotetramer arranged in a tetrahedron which is located exclusively in the mitochondrial matrix. Pyruvate carboxylase is involved in gluconeogenesis, lipogenesis, insulin secretion and synthesis of the neurotransmitter glutamate. Mutations in this gene have been associated with pyruvate carboxylase deficiency. Alternatively spliced transcript variants with different 5' UTRs, but encoding the same protein, have been found for this gene.

A2020 | Anti-Pyruvate Carboxylase Antibody DataSheet

Antibody Target: Pyruvate Carboxylase

Target Alternative Name: Pyruvate carboxylase mitochondrial; Pyruvic carboxylase; PCB

Tag Line: Affinity purified rabbit polyclonal antibody to detect Pyruvate Carboxylase expression in human, mouse, rat bovine, chicken, monkey, porcine, sheep and zebrafish samples

Category: Primary antibody

Host: Rabbit

Isotype: IgG

Species Reactivities: Bovine, Sheep, Zebrafish, Porcine, Rat, Chicken, Monkey, Mouse, Human

Immunogen Sequence: KLH-conjugated synthetic peptide targeting a sequence within the center region of human Pyruvate Carboxylase.

Accession #: P11498

Gene ID: 5091

Appearance: Colorless liquid

Form: Liquid

Concentration:

Formulation: In 0.42% Potassium phosphate; 0.87% NaCl; pH 7.3; 30% glycerol; and 0.01% sodium azide

Purification: Affinity purified

Application: Western Blotting

Positive Control:

Application And Usages: WB 1:500 - 1:1000

Country of Animal Origin: USA

Country of Manufacture: USA

Usage: For Research Use Only! Not to be used in humans.

Handling: The antibody solution should be gently mixed before use.

Western Blot Verified: True

Immunocytochemistry Verified: False

Immunofluorescence Verified: False

Immunoprecipitation Verified: False

FACS Verified: False

ELISA Verified: False

ChIP Verified: False

Dot Blot Verified: False

Flow Cytometry Verified: False