Anti-SIRT1 Polyclonal Antibody | A2345

Sirtuin 1 (SIRT1) is an NAD-dependent protein deacetylase that links transcriptional regulation directly to myriad cellular functions such as cell cycle control, metabolism, apoptosis, and autophagy. SIRT1 can modulate chromatin function through histone deacetylation which leads to transcriptional repression of target genes. SIRT1 can also directly deacetylate transcription factors, which positively and negatively regulates target gene expression depending on the affected transcription factor. Among the proteins affected by SIRT1 are ARNTL, PER2, and CRY1, demonstrating a key role for SIRT1 in the regulation of circadian rhythm.

A2345 | Anti-SIRT1 Polyclonal Antibody DataSheet

Antibody Target: Human SIRT1

Target Alternative Name: Sirtuin 1; SIR2L1; SIR2-Like Protein 1; Sirtuin Type 1; HSIRT1; HSIR2; SIR2

Tag Line: Coordinates cellular functions including cell cycle regulation, metabolism, apoptosis, and autophagy

Category: GM-CSF

Host: Rabbit

Isotype: Rabbit IgG

Species Reactivities: Rat Human

Immunogen Sequence: KLH-conjugated synthetic peptide of human SIRT1

Accession #: Q96EB6

Gene ID: 23411

Appearance: Liquid

Form: Rabbit polyclonal

Concentration:

Formulation: In 0.42% potassium phosphate, 0.87% NaCl, pH 7.3, w/30% glycerol and 0.01% sodium azide

Purification: Immunogen affinity chromatography

Application: Western Blotting Immunofluorescence (IF) Immunohistochemistry (IHC)

Positive Control:

Application And Usages: Western Blotting Immunofluorescence (IF) Immunohistochemistry (IHC)

Country of Animal Origin: USA

Country of Manufacture: USA

Usage: For Research Use Only! Not to be used in humans.

Handling: The antibody solution should be gently mixed before use.

Western Blot Verified: FALSE

Immunocytochemistry Verified: TRUE

Immunofluorescence Verified: FALSE

Immunoprecipitation Verified: TRUE

FACS Verified: FALSE

ELISA Verified: FALSE

ChIP Verified: TRUE

Dot Blot Verified: FALSE

Flow Cytometry Verified: FALSE