26
Anti-SIRT1 Polyclonal Antibody | A2345
- SKU:
- 26-A2345-GEN
- Availability:
- Usually shipped in 5 working days
Description
Sirtuin 1 (SIRT1) is an NAD-dependent protein deacetylase that links transcriptional regulation directly to myriad cellular functions such as cell cycle control, metabolism, apoptosis, and autophagy. SIRT1 can modulate chromatin function through histone deacetylation which leads to transcriptional repression of target genes. SIRT1 can also directly deacetylate transcription factors, which positively and negatively regulates target gene expression depending on the affected transcription factor. Among the proteins affected by SIRT1 are ARNTL, PER2, and CRY1, demonstrating a key role for SIRT1 in the regulation of circadian rhythm.
A2345 | Anti-SIRT1 Polyclonal Antibody DataSheet
Antibody Target: Human SIRT1
Target Alternative Name: Sirtuin 1; SIR2L1; SIR2-Like Protein 1; Sirtuin Type 1; HSIRT1; HSIR2; SIR2
Tag Line: Coordinates cellular functions including cell cycle regulation, metabolism, apoptosis, and autophagy
Category: GM-CSF
Host: Rabbit
Isotype: Rabbit IgG
Species Reactivities: Rat Human
Immunogen Sequence: KLH-conjugated synthetic peptide of human SIRT1
Accession #: Q96EB6
Gene ID: 23411
Appearance: Liquid
Form: Rabbit polyclonal
Concentration:
Formulation: In 0.42% potassium phosphate, 0.87% NaCl, pH 7.3, w/30% glycerol and 0.01% sodium azide
Purification: Immunogen affinity chromatography
Application: Western Blotting Immunofluorescence (IF) Immunohistochemistry (IHC)
Positive Control:
Application And Usages: Western Blotting Immunofluorescence (IF) Immunohistochemistry (IHC)
Country of Animal Origin: USA
Country of Manufacture: USA
Usage: For Research Use Only! Not to be used in humans.
Handling: The antibody solution should be gently mixed before use.
Western Blot Verified: FALSE
Immunocytochemistry Verified: TRUE
Immunofluorescence Verified: FALSE
Immunoprecipitation Verified: TRUE
FACS Verified: FALSE
ELISA Verified: FALSE
ChIP Verified: TRUE
Dot Blot Verified: FALSE
Flow Cytometry Verified: FALSE
Additional Information
Storage Condition: |
-20ºC |
Shipping Condition: |
Gel Pack |
Shelf Life: |
12 months |