BLU-554 | B2359

BLU-554 is a potent inhibitor of recombinant fibroblast growth factor receptor 4 (FGFR4) IC₅₀ < 10 nM). It also inhibits phosphorylation of ERK (IC₅₀ < 10 nM), a marker of FGFR4 inhibition, in MDA-MB-453 breast cancer cells.

BLU-554 is a potent inhibitor of recombinant fibroblast growth factor receptor 4 (FGFR4) IC₅₀ < 10 nM). It also inhibits phosphorylation of ERK (IC₅₀ < 10 nM), a marker of FGFR4 inhibition, in MDA-MB-453 breast cancer cells.

B2359 | BLU-554 DataSheet

Alternate Name/Synonyms:

Appearance: White to off-white solid

Formulation:

CAS Number: 1707289-21-1

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: N/A

Molecular Formula: C₂₄H₂₄Cl₂N₄O₄

Molecular Weight: 503.38

Cell-Permeable?: TRUE

Purity: ≥98% by HPLC

Solubilities: >25 mg/ml (DMSO) in 0

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A potent FGFR4 inhibitor

MDL Number:

PubChem CID: 91885617

SMILES: COC1=CC(=C(C(=C1Cl)C2=CC3=CN=C(N=C3C=C2)NC4COCCC4NC(=O)C=C)Cl)OC

InChi: InChI=1S/C24H24Cl2N4O4/c1-4-20(31)28-16-7-8-34-12-17(16)30-24-27-11-14-9-13(5-6-15(14)29-24)21-22(25)18(32-2)10-19(33-3)23(21)26/h4-6,9-11,16-17H,1,7-8,12H2,2-3H3,(H,28,31)(H,27,29,30)/t16-,17+/m0/s1

InChi Key: InChI Key MGZKYOAQVGSSGC-DLBZAZTESA-N