Description
BLU-554 is a potent inhibitor of recombinant fibroblast growth factor receptor 4 (FGFR4) IC₅₀ < 10 nM). It also inhibits phosphorylation of ERK (IC₅₀ < 10 nM), a marker of FGFR4 inhibition, in MDA-MB-453 breast cancer cells.
BLU-554 is a potent inhibitor of recombinant fibroblast growth factor receptor 4 (FGFR4) IC₅₀ < 10 nM). It also inhibits phosphorylation of ERK (IC₅₀ < 10 nM), a marker of FGFR4 inhibition, in MDA-MB-453 breast cancer cells.
Alternate Name/Synonyms:
Appearance: White to off-white solid
Formulation:
CAS Number: 1707289-21-1
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: N/A
Molecular Formula: C₂₄H₂₄Cl₂N₄O₄
Molecular Weight: 503.38
Cell-Permeable?: TRUE
Purity: ≥98% by HPLC
Solubilities: >25 mg/ml (DMSO) in 0
Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Country of Origin: USA
Tag Line: A potent FGFR4 inhibitor
MDL Number:
PubChem CID: 91885617
SMILES: COC1=CC(=C(C(=C1Cl)C2=CC3=CN=C(N=C3C=C2)NC4COCCC4NC(=O)C=C)Cl)OC
InChi: InChI=1S/C24H24Cl2N4O4/c1-4-20(31)28-16-7-8-34-12-17(16)30-24-27-11-14-9-13(5-6-15(14)29-24)21-22(25)18(32-2)10-19(33-3)23(21)26/h4-6,9-11,16-17H,1,7-8,12H2,2-3H3,(H,28,31)(H,27,29,30)/t16-,17+/m0/s1
InChi Key: InChI Key MGZKYOAQVGSSGC-DLBZAZTESA-N
Additional Information
Storage Condition: |
-20ºC |
Shipping Condition: |
Gel Pack |
Shelf Life: |
36 months |